Polygenic Risk Scales for the Development of Depression Using GWAS with Clinical Validation: Methodology and Study Design in the Russian Population

Depression is one of the leading causes of reduced quality of life and social functioning in patients. The prophylaxis of depression is a priority in preventive medicine. Achievement of prophylaxis requires the opportunity to detect the risk group within the population. i.e., individuals at high gen...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience and behavioral physiology 2021-10, Vol.51 (8), p.1040-1049
Main Authors: Kibitov, A. O., Mazo, G. E., Rakitko, A. S., Kasyanov, E. D., Rukavishnikov, G. V., Ilinsky, V. V., Golimbet, V. E., Shmukler, A. B., Neznanov, N. G.
Format: Article
Language:English
Subjects:
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Disease prevention
Genetic screening
Mental depression
Neurobiology
Neurosciences
Population
Population studies
Preventive medicine
Prophylaxis
Quality of life
Test systems
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Depression is one of the leading causes of reduced quality of life and social functioning in patients. The prophylaxis of depression is a priority in preventive medicine. Achievement of prophylaxis requires the opportunity to detect the risk group within the population. i.e., individuals at high genetic risk of developing depression. This review describes the methodology and design of a project to develop a genetic test system based on a polygenic risk score (PRS) for developing depression taking account of the multiple ethnicity and multicultural nature of the Russian population. The study should yield the first data on the genetic architecture of depression (by the GWAS method) and produce polygenic risk scores (PRS) for developing depression. Development of a genetic test system based on studies of the Russian population in conditions of constantly decreasing costs of genetic studies will provide for an effective transition to the development of preventive medicine in mental health.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-021-01163-6