Synthesis and α-Glucosidase Inhibitory Activity of Ursolic Acid, Lupeol, and Betulinic Acid Derivatives

Seven synthetic derivatives of ursolic acid, lupeol, and betulinic acid ( 1a–1b , 2a–2b , and 3a–3c ) were synthesized to study their α-glucosidase inhibitory activity. Three of them ( 2b , 3b , and 3c ) are new compounds. Among the synthetic derivatives, betulinic acid analogues 3b and 3c exhibited...

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Bibliographic Details
Published in:Chemistry of natural compounds 2021-11, Vol.57 (6), p.1038-1041
Main Authors: Nguyen, Ngoc-Hong, Pham, Duc Dung, Le, Thi-Thanh-Van, Nguyen, Thi-Anh-Tuyet, Huynh, Dinh-Long, Duong, Thuc-Huy, Sichaem, Jirapast
Format: Article
Language:English
Subjects:
Acids
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Glucosidase
Organic Chemistry
Plant Sciences
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Summary:Seven synthetic derivatives of ursolic acid, lupeol, and betulinic acid ( 1a–1b , 2a–2b , and 3a–3c ) were synthesized to study their α-glucosidase inhibitory activity. Three of them ( 2b , 3b , and 3c ) are new compounds. Among the synthetic derivatives, betulinic acid analogues 3b and 3c exhibited the best activity against α-glucosidase and is superior to the positive agent, with IC 50 values of 35.0 ± 3.37 and 34.0 ± 1.24 μM, respectively.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-021-03545-1