Synthesis of a Deuterium-Labeled Globotriaosylceramide Probe for Potential Imaging of Subcellular Localization of Gb3 Using NanoSIMS

Globotriaosylceramide (Gb3) is a cell membrane glycosphingolipid expressed by renal cells and gastrointestinal tract and overexpressed by many carcinomas. Subcellular distribution of this biomarker is highly significant for the development of drugs and therapy of diseases related to its interactions...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2021-10, Vol.57 (10), p.1719-1724
Main Authors: Aly, M. R. E., Azab, I. H. El
Format: Article
Language:English
Subjects:
Biomarkers
Cell membranes
Chemistry
Chemistry and Materials Science
Deuterium
Gastrointestinal system
Imaging techniques
Organic Chemistry
Synthesis
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Summary:Globotriaosylceramide (Gb3) is a cell membrane glycosphingolipid expressed by renal cells and gastrointestinal tract and overexpressed by many carcinomas. Subcellular distribution of this biomarker is highly significant for the development of drugs and therapy of diseases related to its interactions with cell surface. This paper describes a simple method for the synthesis of a deuterium-labeled fatty acyl side chain in its ceramide residue as a probe for those who are interested in NanoSIMS 50-based imaging technique in structural biology.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428021100213