Significance of probiotics in remodeling the gut consortium to enhance the immunity of Caenorhabditis elegans

Summary In the recent past, Caenorhabditis elegans has emerged as one of the leading nematode models for studying host–microbe interactions on molecular, cellular, or organismal levels. In general, morphological and functional similarities of the gut of C. elegans with respect to that of human has b...

Full description

Saved in:
Bibliographic Details
Published in:Genesis (New York, N.Y. : 2000) N.Y. : 2000), 2021-12, Vol.59 (12), p.e23454-n/a
Main Authors: Udayakumar, Prithika, Das, Reena, Kannadasan, Anandbabu
Format: Article
Language:English
Subjects:
Animals
C. elegans
Caenorhabditis elegans
Caenorhabditis elegans - immunology
Caenorhabditis elegans - microbiology
Digestive system
Environmental conditions
Gastrointestinal Microbiome - immunology
Gastrointestinal tract
gut microbiome
Host Microbial Interactions - immunology
Humans
Immune response
Immune system
Immunity
Immunity, Innate - immunology
Immunomodulation
Intestinal microflora
Intestine
longevity
Longevity - immunology
Metabolism
Microbiota
Nematodes
Pathogenesis
Probiotics
Worms
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary In the recent past, Caenorhabditis elegans has emerged as one of the leading nematode models for studying host–microbe interactions on molecular, cellular, or organismal levels. In general, morphological and functional similarities of the gut of C. elegans with respect to that of human has brought in speculations on the study of the intestinal microbiota. On the other hand, probiotics have proved their efficacy in metabolism, development, and pathogenesis thereby inducing an immune response in C. elegans. Nurturing C. elegans with probiotics has led to immunomodulatory effects in the intestinal microbiota, proposing C. elegans as one of the in vivo screening criteria to select potential probiotic bacteria for host health‐promoting factors. The major prospect of these probiotics is to exert longevity toward the host in diverse environmental conditions. The extent of research on probiotic metabolism has shed light on mechanisms of the immunomodulatory effect exerted by the nematode model. This review discusses various aspects of the effects of probiotics in improving the health and mechanisms involved in conferring immunity in C. elegans.
ISSN:1526-954X
1526-968X
DOI:10.1002/dvg.23454