Research progress of a new three-dimensional in vitro model of sports-related traumatic brain injury

Sports-related traumatic brain injury (srTBI) is traumatic brain injury (TBI) caused during exercise, which can cause cognitive and motor dysfunction. At present, the research on the molecular mechanism of srTBI and the development of related drugs mainly rely on monolayer cell culture models and an...

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Bibliographic Details
Published in:Sheng wu yi xue gong cheng xue za zhi 2021-01 (4), p.185
Main Authors: Du, Zuocheng, Wang, Jibo, Zhao, Wen, Chen, Zuo, Ou, Gaozhi
Format: Article
Language:Chinese
Subjects:
Animal models
Brain
Brain research
Cell culture
Cognition
Cognitive ability
Drug development
Head injuries
Medical research
Sports
Three dimensional models
Traumatic brain injury
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Summary:Sports-related traumatic brain injury (srTBI) is traumatic brain injury (TBI) caused during exercise, which can cause cognitive and motor dysfunction. At present, the research on the molecular mechanism of srTBI and the development of related drugs mainly rely on monolayer cell culture models and animal models. However, these models are different from the pathophysiological process of human srTBI in terms of simulating brain cell populations and inflammation, making most of the research results based on the above models difficult to effectively guide clinical treatment. The emerging three-dimensional (3D) in vitro model, as an innovative research tool in the medical field, makes up for the limitation of traditional models in simulating the pathophysiological process of human srTBI, and provides new means for further understanding and cognition of srTBI. Although, there have been reports in the literature about emerging...
ISSN:1001-5515