Synthesis and Anticancer Activity Evaluation of Some Thienopyrimidine Derivatives

The current study focused on effective and straightforward routes for preparing a new series of thieno[2,3- d ]pyrimidine derivatives in addition to their acyclo nucleosides analogue. The chemical structures of the synthesized products have been elucidated through diverse spectroscopy analyses such...

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Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2021-11, Vol.47 (6), p.1312-1323
Main Authors: Mohamed, M. A., Khattab, R. R., Wasfy, A. A. F., Abo-Riya, M. A., El-Kalyoubi, S., Hassan, N. A.
Format: Article
Language:English
Subjects:
Anticancer properties
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cancer
Chemical synthesis
Infrared spectroscopy
Life Sciences
NMR
Nuclear magnetic resonance
Organic Chemistry
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Summary:The current study focused on effective and straightforward routes for preparing a new series of thieno[2,3- d ]pyrimidine derivatives in addition to their acyclo nucleosides analogue. The chemical structures of the synthesized products have been elucidated through diverse spectroscopy analyses such as (IR, NMR, MS, and elemental analyses). Some selected thienopyrimidine derivatives were investigated for their anticancer activity against two human cancer cell lines (HepG-2 and MCF-7). The results revealed that compounds 3-ethyl-2-hydrazineyl-3,5,6,7-tetrahydro-4 H -cyclopenta[4,5]thieno[2,3- d ]pyrimidin-4-oneand3-ethyl-2-(2-glucozylidenehydrazineyl)-3,5,6,7-tetrahydro-4 H -cyclopenta[4,5]thieno[2,3- d ]pyrimidin-4-one showed the most potent anticancer activity.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162021060194