Synthesis and Cytotoxic Studies of Quinazoline-Triazole Hybrid Aza Heterocycles

Herein, we report a series of 1,2,3-triazole combined with quinazoline hybrid heterocyclic compounds by 1,3-dipolar cycloaddition reaction catalyzed by Cu(I). This reaction has been carried out between quinazoline based alkyne and aryl/benzyl azides under optimized conditions. Modification of 4-hydr...

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Bibliographic Details
Published in:Russian journal of general chemistry 2021-11, Vol.91 (11), p.2304-2310
Main Authors: Vodnala, Sumathi, Bhavani, Anagani Kanaka Durga, Pagilla, Shankaraiah, Allam, Muralidhar, Rayala, Nagamani, Mudiraj, Anwita, Babu, Phanithi Prakash
Format: Article
Language:English
Subjects:
Alkynes
Anticancer properties
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cycloaddition
Cytotoxicity
Heterocyclic compounds
NMR
Nuclear magnetic resonance
Potassium carbonate
Triazoles
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Summary:Herein, we report a series of 1,2,3-triazole combined with quinazoline hybrid heterocyclic compounds by 1,3-dipolar cycloaddition reaction catalyzed by Cu(I). This reaction has been carried out between quinazoline based alkyne and aryl/benzyl azides under optimized conditions. Modification of 4-hydroxyquinazoline by propargyl bromide in presence of potassium carbonate gives a corresponding alkyne. Structure of the synthesized compounds has been characterized by IR, 1 H, and 13 C NMR, ESI-Mass, and HRMS spectra. The products have been tested for anticancer activity against C6 glioma cell lines and characterized by moderate cytotoxic activity.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363221110189