Triggered and monitored drug release from bifunctional hybrid nanocomposites

Polymer-coated carbon dot-containing calcium carbonate nanoparticles are reported as unique nanocomposites capable of encapsulating a chemotherapeutic drug and displaying afterglow behaviour. The poly(amino acid) polymeric component enhances nanoparticle dispersion and drug retention in aqueous solu...

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Bibliographic Details
Published in:Polymer chemistry 2021-12, Vol.13 (1), p.1-18
Main Authors: Rowley, Jason V, Wall, Patrick A, Yu, Huayang, Howard, Mark J, Baker, Daniel L, Kulak, Alexander, Green, David C, Thornton, Paul D
Format: Article
Language:English
Subjects:
Amino acids
Aqueous solutions
Calcium carbonate
Carbon
Carbon dots
Doxorubicin
Encapsulation
Fluorescence
Nanocomposites
Nanoparticles
Phosphorescence
Polymer chemistry
Polymer coatings
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Summary:Polymer-coated carbon dot-containing calcium carbonate nanoparticles are reported as unique nanocomposites capable of encapsulating a chemotherapeutic drug and displaying afterglow behaviour. The poly(amino acid) polymeric component enhances nanoparticle dispersion and drug retention in aqueous solution, and can be designed to be cleavable to enable doxorubicin release under acidic conditions. The encapsulated carbon nanodots offer fluorescence and brief afterglow to the nanocomposites at neutral pH, which is lost when the nanocomposites encounter acidic (pH 5) solution. The loss of drug molecules, and fluorescence and phosphorescence provided by the carbon dots, in acidic solution ensures that the reported materials have potential promise as early-stage candidates as devices for monitored payload delivery to acidic environments. Polymer-coated carbon dot-containing calcium carbonate nanoparticles are reported as unique nanocomposites capable of encapsulating a chemotherapeutic drug and displaying afterglow behaviour.
ISSN:1759-9954
1759-9962
DOI:10.1039/d1py01227d