Cerebral A 1 adenosine receptor availability in female and male participants and its relationship to sleep

• Published in: NeuroImage (Orlando, Fla.) Fla.), 2021-12, Vol.245, p.118695
• Main Authors: Pierling, Anna L, Elmenhorst, Eva-Maria, Lange, Denise, Hennecke, Eva, Baur, Diego M, Beer, Simone, Kroll, Tina, Neumaier, Bernd, Aeschbach, Daniel, Bauer, Andreas, Landolt, Hans-Peter, Elmenhorst, David
• Format: Article
• Language: English
• Subjects: Adenosine; Adult; Alcohol; Brain Mapping - methods; Caffeine; Cerebellum; Cortex (cingulate); Dopamine; Female; Females; Fluorodeoxyglucose F18; Gender differences; Globus pallidus; Healthy Volunteers; Humans; Latency; Male; Males; Neuromodulation; Positron emission tomography; Radiopharmaceuticals; Receptor, Adenosine A1 - metabolism; Sex differences; Sex Factors; Sleep; Sleep and wakefulness; Substantia grisea
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2021.118695

The neuromodulator adenosine and its receptors are mediators of sleep-wake regulation which is known to differ between sexes. We, therefore, investigated sex differences in A adenosine receptor (A AR) availability in healthy human subjects under well-rested conditions using [ F]CPFPX and positron emission tomography (PET). [ F]CPFPX PET scans were acquired in 50 healthy human participants (20 females; mean age ± SD 28.0 ± 5.3 years). Mean binding potential (BP ; Logan's reference tissue model with cerebellum as reference region) and volume of distribution (V ) values were calculated in 12 and 15 grey matter brain regions, respectively. [ F]CPFPX BP was higher in females compared to males in all investigated brain regions (p