Subacute exposure to aluminum chloride causes prolonged morphological insults in the ventral male prostate and in the female prostate of adult gerbils

• Published in: Environmental toxicology 2022-02, Vol.37 (2), p.299-309
• Main Authors: Silva Lima, Danilo, Silva Gomes, Liana, Sousa Figueredo, Esther, Silva, Yasmin Inocêncio Fernandes, Silva, Edvaldo Mendes, Souza Bovi, Thais, Taboga, Sebastião Roberto, Marques, Mara Rúbia, Biancardi, Manoel Francisco, Santos, Fernanda Cristina Alcantara
• Format: Article
• Language: English
• Subjects: Aluminium; Aluminum; Aluminum Chloride; androgen receptor; Androgen receptors; Androgens; Animals; Body organs; Cell proliferation; Chlorides; Endocrine disruptors; environmental pollutants; estrogen receptor alpha; Estrogen receptors; Estrogens; Exposure; Female; Females; Food packaging; Food processing; Gerbillinae; Hyperplasia; immunohistochemistry; Immunoreactivity; Male; Males; Metals; Morphology; Oestrogens; Organs; Processed foods; Proliferation; Prostate; Receptors; Receptors, Androgen; Recovery; Restoration; Sex hormones; Testosterone; Toxicity; Utensils; Xenoestrogens
• ISSN: 1520-4081; 1522-7278
• DOI: 10.1002/tox.23398

Aluminum (Al) is a widespread metal in the environment, and is found in fresh or processed foods, household utensils, packaging, and medicines. In addition to its high toxicity, Al can also have estrogenic agonistic effects on target organs. Considering that the Al effects on the prostate are little known, the aim of this study was to evaluate the impact of aluminum chloride (AlCl3) subacute exposure on the morphophysiology of the male ventral prostate and the female prostate of adult gerbils. Furthermore, the glandular restoration capacity in face of the Al insults was evaluated in gerbils that were submitted to 30 days of recovery. Male and female gerbils were orally exposed to AlCl3 (10 mg/kg) for 30 consecutive days. The animals were euthanized 1 day (Al1D) or 30 days (Al30D) after the end of treatment. Prostates were dissected out and processed for structural, ultrastructural and immunohistochemical analyses. Male ventral prostates and female prostates of the Al1D group showed increased cell proliferation, glandular hyperplasia, increased secretory activity and greater androgen receptor immunoreactivity. In males, Al withdrawal (Al30D) allowed a partial recovery of the prostate, as the glandular secretory activity, and frequency of androgen receptor positive cells were similar to the control group. In females, the recuperation interval (Al30D) was not enough to restore the prostatic morphology, since the gland remained hyperplastic, proliferative, and with greater androgen and estrogen receptor immunoreactivity. These data alert to the importance of avoiding Al exposure, since this metal can have a harmful and prolonged action on the prostate.