DEDIFFERENTIATED ENDOMETRIAL CARCINOMA ASSOCIATED WITH ENDOMETRIAL POLYPS WITH STROMAL ATYPIA - A CASE REPORT AND REVIEW OF LITERATURE

According to standardized pathological protocol, we reported several histopathologic parameters as follows: lympho-vascular invasion - present; uterine serosa involvement - absent; cervical stroma involvement - absent; lower uterine segment involvement - present. Surprisingly, most dedifferentiated...

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Bibliographic Details
Published in:Research and science today 2021-10 (2), p.117-123
Main Authors: Evsei, Anca, Birceanu-Corobea, Adelina, Sajin, Maria, Mates, Ioan Nicolae, Copca, Narcis
Format: Article
Language:English
Subjects:
Carcinoma
Cervix
Endometrial cancer
Endometrium
Genomes
Immunotherapy
Literature reviews
Lymphatic system
Menopause
Microsatellite instability
Pathology
Patients
PD-L1 protein
Polyps
Stromal cells
Tumors
Uterine cancer
Uterus
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Summary:According to standardized pathological protocol, we reported several histopathologic parameters as follows: lympho-vascular invasion - present; uterine serosa involvement - absent; cervical stroma involvement - absent; lower uterine segment involvement - present. Surprisingly, most dedifferentiated endometrial carcinomas show microsatellite instability - MSI or are connected to the Lynch syndrome. [...]these subtypes are good candidates for immunotherapy and frequently express the immunohistochemical marker PD-L1 13. [...]we excluded other sarcomatous components. Stromal atypia in endometrial polyps is rare and usually identified in patients that followed tamoxifen treatment15. Since this is not the case with our patient, we concluded that the atypical stromal cells should be interpreted as degenerative in a post menopause patient.
ISSN:2247-4455
2285-9632
DOI:10.38173/RST.2021.22.2.11.117-123