Production yields at the distal fall-off of the β+ emitters 11C and 13N for in-vivo range verification in proton therapy

In proton therapy, Positron Emission Tomography (PET) range verification relies on the comparison of the measured and estimated activity distributions from β+ emitters produced by the proton beam in the patient. The accuracy of the estimated activity distributions is basically that of the underlying...

Full description

Saved in:
Bibliographic Details
Published in:Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2022-01, Vol.190, p.109759, Article 109759
Main Authors: Rodríguez-González, Teresa, Guerrero, Carlos, Jiménez-Ramos, María del Carmen, Lerendegui-Marco, Jorge, Millán-Callado, María de los Ángeles, Parrado, Ángel, Gómez, Joaquín, Quesada, Jose Manuel
Format: Article
Language:English
Subjects:
Activation technique
Bragg curve
Cross-sections
Cyclotrons
Emitters
Foils
Measurement methods
Nuclear cross section
PET range verification
PET scanner
Positron emission
Proton beams
Proton therapy
Radiation therapy
Tomography
Verification
β+ emitters
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In proton therapy, Positron Emission Tomography (PET) range verification relies on the comparison of the measured and estimated activity distributions from β+ emitters produced by the proton beam in the patient. The accuracy of the estimated activity distributions is basically that of the underlying reaction cross section data. In this context, we have developed a new method for measuring β+ production yields combining the multi-foil technique with a clinical PET scanner, resulting in energy differential cross sections from a single irradiation. The method has been applied to the production of C11 (t1/2 = 20.36 min) and Ny13 (t1/2 = 9.97 min), the main candidates for off-line PET range verification, in carbon, nitrogen and oxygen, the main elements of the human body. The energy range studied with the 18 MeV CNA cyclotron corresponds to the distal fall-off of the activity curve, i.e. near the Bragg peak. •Development of a new method to measure the production yield of β+ emitters induced by a beam of charged particles.•Combination of multi-foil activation with detection of the annihilation radiation with a clinical PET scanner.•Reaction studied up to 18 MeV: 14N(p,α)11C, 12C(p,γ)13N, 16O(p,α)13N and 16O(p,3p3n)11C.
ISSN:0969-806X
1879-0895
DOI:10.1016/j.radphyschem.2021.109759