Doege-Potter syndrome: a case report

Introduction Doege-Potter syndrome is a rare paraneoplastic syndrome presenting as hypoinsulinemic hypoglycemia due to ectopic secretion of prohormone: insulin-like growth factor-2 (IGF-2) from a solitary fibrous tumor (SFT). It is essentially a non-islet cell tumor hypoglycemia (NICTH) or in more r...

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Bibliographic Details
Published in:International journal of diabetes in developing countries 2021-10, Vol.41 (4), p.688-691
Main Authors: Yadav, Abhishek, Nawal, C. L., Agrawal, Abhishek, Singh, Aradhana, Chejara, Radhey Shyam
Format: Article
Language:English
Subjects:
Case Report
Case reports
Diabetes
Diabetes mellitus
Family Medicine
General Practice
Health Administration
Hypoglycemia
Hypoxia
Insulin
Insulin-like growth factors
Malignancy
Medicine
Medicine & Public Health
Pancreatic cancer
Paraneoplastic syndrome
Tumors
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Summary:Introduction Doege-Potter syndrome is a rare paraneoplastic syndrome presenting as hypoinsulinemic hypoglycemia due to ectopic secretion of prohormone: insulin-like growth factor-2 (IGF-2) from a solitary fibrous tumor (SFT). It is essentially a non-islet cell tumor hypoglycemia (NICTH) or in more recent terms, an ‘IGF-2oma’. In case of delay in diagnosis, tumor-induced hypoglycemia could cause hypoxic cerebral injury or death. We hereby present a case of 45 years old male who presented with hypoglycemia due to pleural SFT, which is a very rare and unique presentation. Results Upon biochemical and radiological investigations, Doege-Potter syndrome was diagnosed and the patient was planned for surgical resection of the tumor. Conclusion This case stresses upon thorough evaluation of patients presenting with non-diabetic hypoglycemia to rule out underlying malignancy.
ISSN:0973-3930
1998-3832
DOI:10.1007/s13410-021-00938-4