Effect of Chromium Supplementation on Blood Glucose and Lipid Levels in Patients with Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysis

• Published in: Biological trace element research 2022-02, Vol.200 (2), p.516-525
• Main Authors: Zhao, Fengyi, Pan, Da, Wang, Niannian, Xia, Hui, Zhang, Hong, Wang, Shaokang, Sun, Guiju
• Format: Article
• Language: English
• Subjects: Biochemistry; Biomedical and Life Sciences; Biotechnology; Blood; Blood Glucose; Blood levels; Cholesterol; Chromium; Chromium - administration & dosage; Clinical trials; Data analysis; Density; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - drug therapy; Dietary Supplements; Fasting; Glucose; Glucose metabolism; Glycated Hemoglobin A - analysis; Hemoglobin; High density lipoprotein; Humans; Laboratory testing; Life Sciences; Lipid metabolism; Lipids; Lipids - blood; Lipoproteins; Low density lipoprotein; Meta-analysis; Metabolism; Nutrition; Oncology; Quality assessment; Randomized Controlled Trials as Topic; Statistical analysis; Statistical methods; Supplements; Triglycerides
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-021-02693-3

In recent years, the prevalence and incidence of diabetes mellitus (DM) have increased sharply worldwide. In order to evaluate the effect of chromium supplementation on patients with type 2 diabetes, a meta-analysis was conducted by searching the relevant literature. Randomized controlled trials on the effects of chromium supplements on glucose metabolism or lipid profile in patients with type 2 diabetes were retrieved from multiple databases. Literature screening, quality evaluation, and data extraction were conducted according to the inclusion and exclusion criteria, and Review Manager 5.4.0 was used for data analysis. A total of 10 randomized controlled trials involving 509 patients were included, including 269 cases in the experimental group and 240 cases in the placebo control group. Statistical analysis was conducted on the glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) to evaluate the blood glucose and lipid levels. Meta-analysis results showed that the differences between the experimental group and the control group in only one indicator of HbA1c were statistically significant, while there were no statistically significant differences in other indicators. The use of chromium supplements can reduce the glycosylated hemoglobin of type 2 diabetic patients to a certain extent, but it cannot effectively improve the fasting blood glucose and blood lipid levels of type 2 diabetic patients.