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Design and preparation of oral jelly candies of acetaminophen and its nanoparticles

Jelly candy is a novel and promising method for advanced drug delivery, especially among children due to the enjoyable taste of candy products. The anti-fever and analgistic properties of acetaminophen in the effective treatment of mild to moderate pain has been well-studied over the past few decade...

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Bibliographic Details
Published in:Applied nanoscience 2022, Vol.12 (1), p.101-107
Main Authors: Hosseini, Amin, Bagheri, Fereshteh, Mohammadi, Ghobad, Azami, Mahsa, Tahvilian, Reza
Format: Article
Language:English
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Summary:Jelly candy is a novel and promising method for advanced drug delivery, especially among children due to the enjoyable taste of candy products. The anti-fever and analgistic properties of acetaminophen in the effective treatment of mild to moderate pain has been well-studied over the past few decades. This study aims to prepare a novel dosage form of acetaminophen nanoparticles jelly candies that are suitable for children to consume. Polyethylene glycol 6000 was dissolved in distilled water and then acetaminophen powder dissolved in ethanol, added rapidly to the stirring solution of polyethylene glycol 6000. Gelling agents consisting of gelatin and starch were added to the nanoparticle solution. The final solution was stirred well and allowed to dry at refrigerator temperature for 24 h. Characterization tests such as DSC, FT-IR spectroscopy, surface electron microscopy (SEM) and transmission electron microscopy (TEM) imaging, and release profiles of both nanoparticles and jelly candies were done. FT-IR results confirmed the formation of nanoparticles. The size of the synthesized nanoparticles was about 38–50 nm. Cumulative drug release of the nanoparticles in the jelly candies was about 74% after 24 h, the the nanoparticles’ release profile obeys the Hixon–Crowell model, and the jelly candies show first-order release profiles. The oral jelly candies loaded with nanoparticles can be the next generation of novel dosage forms of acetaminophen because of their ease of consumption and higher compliance among children than the conventional oral tablets. Further studies are needed to confirm these findings.
ISSN:2190-5509
2190-5517
DOI:10.1007/s13204-021-02231-6