A Review of Antimicrobial Peptides: Its Function, Mode of Action and Therapeutic Potential

Antimicrobial peptides (AMPs) are endogenous polypeptides produced by multicellular organisms in order to protect a host from pathogenic microbes. AMPs are also defined as host defense peptides because of their essential role in constituting the innate immunity system. The major mechanism of actions...

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Bibliographic Details
Published in:International journal of peptide research and therapeutics 2022, Vol.28 (1), Article 46
Main Authors: Nayab, Sehrish, Aslam, Muhammad Aamir, Rahman, Sajjad ur, Sindhu, Zia ud Din, Sajid, Sanaullah, Zafar, Nishat, Razaq, Maida, Kanwar, Rabia, Amanullah
Format: Article
Language:English
Subjects:
Animal Anatomy
Antibiotics
Antimicrobial agents
Antimicrobial peptides
Biochemistry
Biomedical and Life Sciences
Cell membranes
Drug resistance
Histology
Immune response
Innate immunity
Life Sciences
Molecular Medicine
Morphology
Pathogens
Peptides
Pharmaceutical Sciences/Technology
Pharmacology/Toxicology
Polymer Sciences
Wound healing
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Summary:Antimicrobial peptides (AMPs) are endogenous polypeptides produced by multicellular organisms in order to protect a host from pathogenic microbes. AMPs are also defined as host defense peptides because of their essential role in constituting the innate immunity system. The major mechanism of actions against microbial pathogens is attributed to perturbation of cell membrane of pathogens. In addition to the antimicrobial function, AMPs also act as effector molecules in wound healing, inflammation, and immune activation. AMPs have been considered as a potential therapeutic source due to its different mechanism of actions and broad-spectrum properties in comparison with the conventionally used antibiotics. As a new generation antibiotic, the AMPs have considerable benefits. AMPs are receiving great attention as promising alternatives to conventional antibiotics to overcome the current drug resistance crisis. In this review, we describe the classes, structural information about AMPs and their therapeutic role as novel antibiotic agents.
ISSN:1573-3149
1573-3904
DOI:10.1007/s10989-021-10325-6