Orthotopic heart transplant in a pediatric patient with mixed connective tissue disease

Background Patients with autoimmune inflammatory syndromes such as mixed connective tissue disease (MCTD) and systemic lupus erythematosus have previously been considered marginal candidates for orthotopic heart transplant (OHT). Methods A retrospective chart review was completed for this case repor...

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Bibliographic Details
Published in:Pediatric transplantation 2022-02, Vol.26 (1), p.e14144-n/a
Main Authors: Miller, Chelsea, White, Shelby, L’Ecuyer, Thomas, McCulloch, Michael
Format: Article
Language:English
Subjects:
autoimmune disease
Autoimmune diseases
Child
Congestive heart failure
Connective tissue diseases
Female
Graft rejection
Heart Failure - diagnosis
Heart Failure - etiology
Heart Failure - surgery
Heart Transplantation
Heart transplants
Humans
Inflammation
Mixed connective tissue disease
Mixed Connective Tissue Disease - diagnosis
Mixed Connective Tissue Disease - physiopathology
Mixed Connective Tissue Disease - surgery
orthotopic heart transplant
Patients
Pediatrics
Systemic lupus erythematosus
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Summary:Background Patients with autoimmune inflammatory syndromes such as mixed connective tissue disease (MCTD) and systemic lupus erythematosus have previously been considered marginal candidates for orthotopic heart transplant (OHT). Methods A retrospective chart review was completed for this case report. Results We present the case of an 11‐year‐old girl with known MCTD who developed congestive heart failure refractory to medical therapy and underwent OHT. Conclusions Despite her autoimmune condition, this patient has not experienced antibody‐mediated rejection post‐transplant and her inflammatory symptoms have greatly improved.
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.14144