Assessment toll_like receptor 4 (TLR4) in thrombocytopenia patients in Holy-Najaf

• Main Authors: Al-Fatlawi, Noor Alhuda Ghanem, Al-Dujaili, Arshad N. G., Kammona, Talib H. Nooruldeen, Aldujaili, Hadeel Haider
• Format: Conference Proceeding
• Language: English
• Subjects: Autoimmune diseases; Blood; Body mass index; Body size; Correlation; Leukocytes; Platelets; Receptors; Subgroups; Thrombocytopenia; Weight
• ISSN: 0094-243X; 1551-7616
• DOI: 10.1063/5.0067114

"thrombocytopenia" may be characters by a reduction the platelet counts in blood. Primary "thrombocytopenia" or idiopathic "thrombocytopenia" purpura (ITP) is an autoimmune disorder of unknown condition and "thrombocytopenia" that a result of a known condition called secondary "thrombocytopenia". TLR4 Receptor like in conformity with CD14 (the molecule as bound for transferring LPS in accordance with TLR4), the ectodomains concerning TLR4 are horse shoe- shaped fit in accordance with the presence over various leucin-rich repeats (LRRs). TLR4 important roles in pathophysiology related to the many autoimmune disorder like "thrombocytopenia". The study was applied on 85 people aged 20 to 69 year; 65 patients group with "thrombocytopenia" and 30 healthy group as a control group in Holy-Najaf. The patients group were divided into subgroups supported gender, age, body mass index (BMI), primary and secondary "thrombocytopenia". The complete blood count were examined for all patients group and healthy group. TLR4 serum level was significantly increase( P< 0.05) in "thrombocytopenia" patients compared than controls. Primary "thrombocytopenia" show significant increase (P< 0.05) in TLR4 serum than secondary "thrombocytopenia". The results exhibited non a significant increase (P>0.05) in serum TLR4 level in female patients group compared with male patients group. Also the results indicated non-significant differences (P>0.05) in serum TLR4 level of patients at different ages group and different types of body mass index (normal weight, over weight and obese weight) respectively. The results of correlation and linear regression indicated significant negative (P0.05) correlation between TLR4 and leucocyte counts in primary "thrombocytopenia" while non- significant positive correlation between TLR4 and platelets concentrations and non-significant negative correlation (P>0.05) between TLR4 and leucocytes counts of secondary "thrombocytopenia". The aim of study is estimation TLR4 in thrombocytopenia and find out the association between the gender, age, body mass index (BMI) with TLR4 levels in serum.