Extracellular Matrix in Synthetic Hydrogel‐Based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 Inhibitors (Adv. Mater. 2/2022)

Cancer Therapy In article number 2100096, Olivier Elemento, Ankur Singh, and co‐workers examine the prostate cancer tumor microenvironment using multi‐omics techniques and report a prostate cancer organoid bioengineered using a modular synthetic hydrogel that shapes the epigenetics and transcriptomi...

Full description

Saved in:
Bibliographic Details
Published in:Advanced materials (Weinheim) 2022-01, Vol.34 (2), p.n/a
Main Authors: Mosquera, Matthew J., Kim, Sungwoong, Bareja, Rohan, Fang, Zhou, Cai, Shuangyi, Pan, Heng, Asad, Muhammad, Martin, Maria Laura, Sigouros, Michael, Rowdo, Florencia M., Ackermann, Sarah, Capuano, Jared, Bernheim, Jacob, Cheung, Cynthia, Doane, Ashley, Brady, Nicholas, Singh, Richa, Rickman, David S., Prabhu, Varun, Allen, Joshua E., Puca, Loredana, Coskun, Ahmet F., Rubin, Mark A., Beltran, Himisha, Mosquera, Juan Miguel, Elemento, Olivier, Singh, Ankur
Format: Article
Language:English
Subjects:
Bioengineering
chemoresistance
Dopamine
dopamine receptors
epigenetics
Hydrogels
Materials science
neuroendocrine
Prostate cancer
tumor microenvironment
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cancer Therapy In article number 2100096, Olivier Elemento, Ankur Singh, and co‐workers examine the prostate cancer tumor microenvironment using multi‐omics techniques and report a prostate cancer organoid bioengineered using a modular synthetic hydrogel that shapes the epigenetics and transcriptomics of cancer cells. They discover the “dopamine receptor” pathway as a targeted therapy for epigenetically reprogrammed neuroendocrine prostate cancers.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.202270014