Neurophysiological correlate of incubation of craving in individuals with methamphetamine use disorder

Previous studies both in laboratory animals and humans have reported that abstinence induces incubation of cue-induced drug craving for nicotine, alcohol, cocaine, and methamphetamine. However, current experimental procedures utilized to study incubation of methamphetamine craving do not incorporate...

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Bibliographic Details
Published in:Molecular psychiatry 2021-11, Vol.26 (11), p.6198-6208
Main Authors: Zhao, Di, Zhang, Mingming, Tian, Weiwen, Cao, Xinyu, Yin, Lu, Liu, Yi, Xu, Tian-Le, Luo, Wenbo, Yuan, Ti-Fei
Format: Article
Language:English
Subjects:
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Amphetamine abuse
Animals
Anxiety
Behavioral Sciences
Biological Psychology
Cocaine
Cocaine - pharmacology
Craving
Cross-Sectional Studies
Cues
Desire
Drug addiction
EEG
Electroencephalography
Health aspects
Immediate Communication
Impulsive behavior
Impulsivity
Laboratory animals
Male
Medicine
Medicine & Public Health
Mental depression
Methamphetamine
Methamphetamine - pharmacology
Neural networks
Neuromodulation
Neurophysiology
Neuropsychology
Neurosciences
Nicotine
Pharmacotherapy
Physiological aspects
Prefrontal cortex
Psychiatry
Satiation
Sleep
Synchronization
Temporal cortex
Therapeutic applications
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Summary:Previous studies both in laboratory animals and humans have reported that abstinence induces incubation of cue-induced drug craving for nicotine, alcohol, cocaine, and methamphetamine. However, current experimental procedures utilized to study incubation of methamphetamine craving do not incorporate the temporal dynamics of neuropsychological measures and electrophysiological activities associated with this incubation process. This study utilized the high-density electroencephalogram (EEG) signals as a rapid, inexpensive, and noninvasive measure of cue-induced craving potential. A total of 156 male individuals with methamphetamine use disorder (MUD) enrolled in this multisite, cross-sectional study. Structured clinical interview data, self-report questionnaires (cued craving, quality of sleep, impulsivity, anxiety, and depression) and resting-state, eye-closed 128 high-density channel EEG signals were collected at 5 abstinence duration time points (
ISSN:1359-4184
1476-5578
DOI:10.1038/s41380-021-01252-5