Fabrication of copper ions-substituted hydroxyapatite coating on titanium substrates for antibacterial and osteogenic applications

•Composite coating of HA-Cu was fabricated on titanium dioxide nanotubes (TNT) substrates.•TNT-HA-Cu exhibits strong antibacterial property against E. coli and S. aureus.•TNT-HA-Cu was biocompatible and could induce osteogenesis. The aim of this study was to enhance the antibacterial property and os...

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Bibliographic Details
Published in:Materials letters 2022-01, Vol.307, p.131072, Article 131072
Main Authors: Yu, Yonglin, Lin, Chuanchuan, Wu, Meng, Tao, Bailong
Format: Article
Language:English
Subjects:
Antibacterial
Biocompatibility
Biomaterials
Biomedical materials
Contact angle
Copper
Crystal structure
E coli
Electron microscopes
Functional
Gene expression
Hydroxyapatite
Materials science
Morphology
Nanoparticles
Orthopedics
Osteogenic effect
Protective coatings
Substitutes
Substrates
Surgical implants
TiO2 nanotubes
Titanium
Titanium dioxide
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Summary:•Composite coating of HA-Cu was fabricated on titanium dioxide nanotubes (TNT) substrates.•TNT-HA-Cu exhibits strong antibacterial property against E. coli and S. aureus.•TNT-HA-Cu was biocompatible and could induce osteogenesis. The aim of this study was to enhance the antibacterial property and osteogenic ability of copper ions-substituted hydroxyapatite (HA-Cu)-based titanium dioxide nanotubes (TNT) implants. The morphology and crystal structure of HA-Cu nanoparticles were characterized by transmission electron microscope (TEM) and X-ray diffraction (XRD). Morphologies and hydrophilic property of Ti, TNT, TNT-HA, and TNT-HA-Cu were evaluated by scanning electron microscope (SEM) and water contact angle (WCA) measurement. Antibacterial assays confirmed that the TNT-HA-Cu presented strong antibacterial abilities against E. coli (82.3%) and S. aureus (87.0%) compared with native Ti substrates. Cellular experiments indicated that TNT-HA-Cu was biocompatible and could induce osteogenesis by stimulating osteoblasts adhesion, proliferation, differentiation, and up-regulating the expression of osteogenic-related genes. The HA-Cu modified TNT substrates were an effective approach of designing both antibacterial and osteogenic Ti-based implants in the orthopedic field.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2021.131072