Injectable nanocomposite hydrogel as wound dressing agent with tunable multifunctional property

•Injectable nanocomposite hydrogel with multifunctional properties was developed.•The hydrogel showed shear-thinning properties.•The hydrogel showed good biocompatibility, hemostasis, and antibacterial activity.•Hydrogel nanocomposite can be used as a potential wound dressing agent. An injectable na...

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Bibliographic Details
Published in:Materials letters 2022-01, Vol.307, p.131062, Article 131062
Main Authors: Rao, Kummara Madhusudana, Suneetha, Maduru, Zo, Sunmi, Won, So Yeon, Kim, Hyeon Jin, Han, Sung Soo
Format: Article
Language:English
Subjects:
Cell adhesion
Chitosan
Hemostatics
Hydrogel
Hydrogels
Injectable
Materials science
Multifunctional
Nanocomposite
Nanocomposites
Nanoparticles
Shear thinning (liquids)
Silver
Tannic acid
Wound dressing
Wound healing
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Summary:•Injectable nanocomposite hydrogel with multifunctional properties was developed.•The hydrogel showed shear-thinning properties.•The hydrogel showed good biocompatibility, hemostasis, and antibacterial activity.•Hydrogel nanocomposite can be used as a potential wound dressing agent. An injectable nanocomposite hydrogel with tunable multifunctional properties such as cell adhesive, antibacterial, and hemostasis, was developed. The nanocomposite hydrogel consisted of natural non-animal fungal mushroom-derived carboxymethyl chitosan (F-CMCS), and tannic acid stabilized silver (TA-Ag) nanoparticles. The hydrogel showed shear-thinning properties that could be injected for minimally invasive approaches. The hydrogels showed improved cell adhesion and spreading, hemostasis, and antibacterial activity. Thus, this multifunctional injectable hydrogel nanocomposite can be used as a potential wound dressing agent.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2021.131062