From imines to amides via NHC-mediated oxidation

The unprecedented NHC-mediated oxidation of imines to amides is described. This protocol features broad substrate scope and allows rapid assembly of amides in good to high yields. Notably, this process includes not only the umpolung of imines, but also the discovery of NHC-bound 1,2-dioxetane interm...

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Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2022-01, Vol.9 (2), p.356-363
Main Authors: Sun, Shaofa, Guo, Donghui, Li, Fangyi, Wang, Jian
Format: Article
Language:English
Subjects:
Amides
Imines
Intermediates
Organic chemistry
Oxidation
Substrates
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Description
Summary:The unprecedented NHC-mediated oxidation of imines to amides is described. This protocol features broad substrate scope and allows rapid assembly of amides in good to high yields. Notably, this process includes not only the umpolung of imines, but also the discovery of NHC-bound 1,2-dioxetane intermediates.
ISSN:2052-4110
2052-4110
DOI:10.1039/d1qo01661j