Domino 1,4‐ and 1,4‐Addition Reactions of Ketene Silyl Thioacetals to Dialkynyl Imines Promoted by Scandium Triflate: Synthesis of Multifunctionalized δ‐Lactams

Domino 1,4‐ and 1,4‐addition reactions of ketene silyl thioacetals to dialkynyl imines are disclosed. Scandium triflate promoted domino 1,4‐ and 1,4‐addition reactions of ketene silyl thioacetals to dialkynyl imines to give a variety of alkynyl δ‐lactams in moderate to good yields. Synthesis of mult...

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Bibliographic Details
Published in:Asian journal of organic chemistry 2022-01, Vol.11 (1), p.n/a
Main Authors: Watanabe, Yuya, Isaka, Keisuke, Sato, Koki, Kokado, Shinya, Mizutani, Amane, Hachiya, Iwao
Format: Article
Language:English
Subjects:
1,4-Addition
Alkynyl imine
Cascade chemical reactions
Domino reaction
Imines
Organic chemistry
Scandium
Scandium triflate
δ-Lactam
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Summary:Domino 1,4‐ and 1,4‐addition reactions of ketene silyl thioacetals to dialkynyl imines are disclosed. Scandium triflate promoted domino 1,4‐ and 1,4‐addition reactions of ketene silyl thioacetals to dialkynyl imines to give a variety of alkynyl δ‐lactams in moderate to good yields. Synthesis of multifunctionalized δ‐lactams is developed using scandium triflate‐promoted domino 1,4‐ and 1,4‐addition reactions of ketene silyl thioacetals to dialkynyl imines.
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.202100672