Environmentally Conscious In-Water Peptide Synthesis Using Boc Strategy

Seeking a more environmentally balanced method of peptide synthesis, we are focusing on developing organic solvent-free synthetic methods using water, an environmentally friendly solvent. In current peptide synthesis, the most common building blocks are Boc- and Fmoc-protected amino acids, which are...

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Bibliographic Details
Published in:International journal of peptide research and therapeutics 2022-03, Vol.28 (2), Article 51
Main Authors: Hojo, Keiko, Fujiwara, Suzuko, Inai, Hoshito, Manabe, Yuki, Tsuda, Yuko
Format: Article
Language:English
Subjects:
Advances in peptide therapeutics
Amino acids
Animal Anatomy
Biochemistry
Biomedical and Life Sciences
Histology
Life Sciences
Molecular Medicine
Morphology
Nanoparticles
Peptide synthesis
Peptides
Pharmaceutical Sciences/Technology
Pharmacology/Toxicology
Polymer Sciences
Solvents
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Summary:Seeking a more environmentally balanced method of peptide synthesis, we are focusing on developing organic solvent-free synthetic methods using water, an environmentally friendly solvent. In current peptide synthesis, the most common building blocks are Boc- and Fmoc-protected amino acids, which are highly soluble in organic solvents. We previously reported a technique for solid-phase peptide synthesis in water that utilizes Fmoc-amino acids converted to water-dispersible nanoparticles. The Boc strategy is well-known to be suitable for the industrial chemistry and green chemistry, because only gases are generated without any other by-products in the deprotection step of Boc group. Here we summarize in-water both liquid and solid-phase method using Boc-amino acids based on MW-assisted coupling reaction of nanosized reactants, nanoparticles and nanomicelles.
ISSN:1573-3149
1573-3904
DOI:10.1007/s10989-021-10354-1