Medical and aesthetic improvement of photodamaged skin by the combination of intense pulsed light and photodynamic therapy with 10% aminolevulinic acid hydrochloride gel

Objective To evaluate the efficacy and safety of photodynamic therapy (PDT) with the novel 10% aminolevulinic acid (ALA) hydrochloride gel (10% ALA gel) and BF‐RhodoLED® light (635 nm; 37 J/cm2) in combination with intense pulsed light (IPL) to augment the medical and aesthetic improvement of photod...

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Bibliographic Details
Published in:Lasers in surgery and medicine 2022-01, Vol.54 (1), p.62-65
Main Authors: Abrouk, Michael, Dong, Joanna, Waibel, Jill S.
Format: Article
Language:English
Subjects:
Ameluz
Aminolevulinic acid
Aminolevulinic Acid - therapeutic use
BF‐RhodoLED
Chest
décolletéIP
Esthetics
Female
Humans
IPL
Light effects
otodamageph
otodynamic therapyre
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - therapeutic use
Pilot Projects
Prospective Studies
rejuvenation
Skin
Tph
Treatment Outcome
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Summary:Objective To evaluate the efficacy and safety of photodynamic therapy (PDT) with the novel 10% aminolevulinic acid (ALA) hydrochloride gel (10% ALA gel) and BF‐RhodoLED® light (635 nm; 37 J/cm2) in combination with intense pulsed light (IPL) to augment the medical and aesthetic improvement of photodamaged skin of the décolleté. Methods This was a single‐site prospective, randomized, intraindividual split chest pilot study with 20 female subjects with moderate to severe photodamage of the décolleté. Subjects were randomized to ALA‐PDT + IPL to one split‐side of the chest and ALA‐PDT only to the contralateral side. Three blinded raters assessed aesthetic improvement using the global aesthetic improvement scale (GAIS). Results Eighteen subjects completed the study. Superior GAIS results were achieved on the ALA‐PDT + IPL treatment side than on the ALA‐PDT only treatment side (p 
ISSN:0196-8092
1096-9101
DOI:10.1002/lsm.23460