Lipocalin, Resistin and Gut Microbiota-Derived Propionate Could Be Used to Predict Metabolic Bariatric Surgery Selected Outcomes

• Published in: Processes 2022-01, Vol.10 (1), p.143
• Main Authors: Auguet, Teresa, Lopez-Dupla, Miguel, Ramos, Jessica, Bertran, Laia, Riesco, David, Aguilar, Carmen, Ardévol, Anna, Pinent, Montserrat, Sabench, Fàtima, Del Castillo, Daniel, Richart, Cristóbal
• Format: Article
• Language: English
• Subjects: Adiponectin; Biomarkers; Body fat; Body mass index; Cytokines; Density; Digestive system; Disease; Gastrointestinal surgery; Gastrointestinal tract; Glucose; Hemoglobin; High density lipoprotein; IL-1β; Insulin; Insulin resistance; Interleukin 10; Interleukin 8; Intestinal microflora; Laparoscopy; Leptin; Lipocalin; Low density lipoprotein; Metabolism; Metabolites; Microbiota; Obesity; Peptides; Propionic acid; Remission (Medicine); Side effects; Surgery; Triglycerides; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Variables; Weight control; Womens health
• ISSN: 2227-9717; 2227-9717
• DOI: 10.3390/pr10010143

Many patients with clinically severe obesity (CSO) need to undergo bariatric surgery, with possible side effects, so individualized predictive methods are required. Adipocytokines and gut/intestinal microbiota-derived metabolites could be predictive biomarkers of metabolic success post- surgery, but the knowledge in this field is undefined. The objective of this work was to determine whether adipocytokines and microbiota-derived metabolites can be used to predict the metabolic improvement post- surgery in women with CSO. We analyzed circulating levels of some cytokines and some microbiota-derived metabolites at baseline and 12 months post-surgery from 44 women with CSO and 21 women with normal weight. Results showed that glucose, insulin, glycosylated hemoglobin A1c (HbA1c), low-density lipoprotein (LDL-C), and triglycerides levels were decreased post-surgery, while high density lipoprotein increased. Twelve months later, leptin, resistin, lipocalin, PAI-1, TNF-α, and IL-1β levels were lower than baseline, meanwhile adiponectin, IL-8, and IL-10 levels were increased. Moreover, baseline lipocalin levels were associated with HbA1c reduction post-surgery; meanwhile baseline resistin was related to postoperative HOMA2 (insulin resistance) and baseline propionate was associated with LDL-C decrease. To conclude, the detection of lipocalin, resistin, and propionate levels may be used to predict the metabolic success following bariatric surgery, although new knowledge is needed.