Peptide Amphiphile Hydrogels Based on Homoternary Cucurbit[8]uril Host-Guest Complexes

Supramolecular hydrogels based on peptide amphiphiles (PAs) are promising materials for tissue engineering and model extracellular matrixes for biological studies. While PA hydrogels are conventionally formed via electrostatic screening, new hydrogelation mechanisms might help to improve the design...

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Bibliographic Details
Published in:Bioconjugate chemistry 2022-01, Vol.33 (1), p.111-120
Main Authors: Redondo-Gómez, Carlos, Padilla-Lopátegui, Soraya, Mata, Alvaro, Azevedo, Helena S
Format: Article
Language:English
Subjects:
Amino acids
Animals
Biocompatible Materials - chemistry
Biomedical materials
Bridged-Ring Compounds - chemistry
Crosslinking
Design improvements
Electrostatic properties
Heterocyclic Compounds, 2-Ring
Hydrogels
Hydrogels - chemistry
Imidazoles - chemistry
Imidazolidines
Macrocyclic Compounds
Mice
Nanofibers
Nanofibers - chemistry
Peptides
Peptides - chemistry
Stiffness
Supramolecular compounds
Tissue engineering
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Summary:Supramolecular hydrogels based on peptide amphiphiles (PAs) are promising materials for tissue engineering and model extracellular matrixes for biological studies. While PA hydrogels are conventionally formed via electrostatic screening, new hydrogelation mechanisms might help to improve the design and functionality of these materials. Here, we present a host-guest-mediated PA hydrogelation method that relies on the formation of a host-guest homoternary complex with cucurbit[8]uril ( ) and aromatic amino-acid-bearing PA nanofibers. As a result of the host-guest cross-linking between PA nanofibers, hierarchical morphologies and increased stiffness were found when host-guest-mediated PA hydrogels were compared to their ion-based equivalents. Additionally, both families of hydrogels exhibited similar biocompatibilities. These results demonstrate that -mediated hydrogelation can be used as an alternative cross-linking method to upgrade the design of PA materials and extend their biomedical applications.
ISSN:1043-1802
1520-4812
DOI:10.1021/acs.bioconjchem.1c00441