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Thermal characterization and stability evaluation of leishmanicidal selenocyanate and diselenide derivatives

In this study, the thermal behavior of a series of leishmanicidal selenocyanate and diselenide biological active compounds has been studied by means of differential scanning calorimetry, X-ray diffraction and thermogravimetry in order to establish thermal stability criteria and investigate their pol...

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Bibliographic Details
Published in:Journal of thermal analysis and calorimetry 2022-02, Vol.147 (4), p.3127-3139
Main Authors: Etxebeste, Mikel, Durán, Adrián, Sanmartín, Carmen, González-Peñas, Elena, Plano, Daniel, Lizarraga, Elena
Format: Article
Language:English
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Summary:In this study, the thermal behavior of a series of leishmanicidal selenocyanate and diselenide biological active compounds has been studied by means of differential scanning calorimetry, X-ray diffraction and thermogravimetry in order to establish thermal stability criteria and investigate their polymorphism. Moreover, stability under acid, alkaline and oxidative media was tested using high-performance liquid chromatography with fluorescence detection. The results of the experiments show that there are five types of polymorphic behaviors for the studied compounds. In addition, relationship is found among stability and a series of structural effects and stress conditions of compounds.
ISSN:1388-6150
1588-2926
DOI:10.1007/s10973-020-10544-x