Iron‐Catalyzed Alkene Trifluoromethylation in Tandem with Phenol Dearomatizing Spirocyclization: Regioselective Construction of Trifluoromethylated Spirocarbocycles

In the presence of Fe(III) complex and Bipy ligand, CF3‐containing spirocarbocycles were conveniently obtained in 20–99% yields with high regioselectivity through Iron‐catalyzed trifluoromethylation of unactivated alkenes coupled with phenol dearomatizing spirocyclization.

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2022-02, Vol.364 (3), p.637-642
Main Authors: Zhao, Yilin, Wang, Xue, Yao, Ru, Li, Chengwen, Xu, Zelin, Zhang, Liming, Han, Guifang, Hou, Jingli, Liu, Yangping, Song, Yuguang
Format: Article
Language:English
Subjects:
Alkenes
Coordination compounds
Dearomatization
Iron
Organic chemistry
Phenols
Radical reaction
Regioselectivity
Spirocarbocycle
Trifluoromethylation
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Description
Summary:In the presence of Fe(III) complex and Bipy ligand, CF3‐containing spirocarbocycles were conveniently obtained in 20–99% yields with high regioselectivity through Iron‐catalyzed trifluoromethylation of unactivated alkenes coupled with phenol dearomatizing spirocyclization.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202101201