Extremely high anti‐Mullerian hormone levels detected during infertility workup revealing sex cord tumor with annular tubules and underlying Peutz–Jeghers syndrome: A case report

We report an infertile, but otherwise asymptomatic woman, whose extremely high anti‐Mullerian hormone (AMH) level detected during infertility investigation led to the diagnosis of sex cord tumor with annular tubules (SCTAT) which is a very rare sex cord‐stromal tumor (SCST) and eventually revealed a...

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Bibliographic Details
Published in:The journal of obstetrics and gynaecology research 2022-02, Vol.48 (2), p.492-496
Main Authors: Yucel Cicek, Ozge Senem, Gezer, Sener, Cakir, Ozgur, Hekimoglu Gurbuz, Rumeysa
Format: Article
Language:English
Subjects:
Adult
Anti-Mullerian Hormone
Case reports
Cysts
Diagnosis
Female
Humans
Infertility
Infertility, Female - diagnosis
Infertility, Female - etiology
Ovarian Neoplasms
Ovaries
Peutz-Jeghers Syndrome - complications
Peutz-Jeghers Syndrome - diagnosis
Peutz-Jeghers Syndrome - genetics
Peutz–Jeghers syndrome
preimplantation genetic testing
Sex
sex cord tumor with annular tubules
Sex Cord-Gonadal Stromal Tumors - complications
Sex Cord-Gonadal Stromal Tumors - diagnosis
Tubules
Tumors
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Summary:We report an infertile, but otherwise asymptomatic woman, whose extremely high anti‐Mullerian hormone (AMH) level detected during infertility investigation led to the diagnosis of sex cord tumor with annular tubules (SCTAT) which is a very rare sex cord‐stromal tumor (SCST) and eventually revealed a previously undiagnosed hereditary cancer syndrome, Peutz–Jeghers syndrome (PJS). A 33‐year‐old woman attended Kocaeli University ART Clinic for infertility evaluation. Her AMH level was 319.63 ng/ml. Detection of bilateral ovarian cysts required surgical evaluation. The histopathological examination of ovaries revealed SCTAT. The strong association of SCTAT with PJS raised the suspicion of this syndrome. Whole STK11 gene sequencing confirmed PJS diagnosis. AMH has become a widely used tool in the evaluation of infertile women. Clinicians dealing with infertility should be familiar with the utility of AMH measurement besides being a marker of ovarian reserve. Detection of high AMH concentrations should raise the suspicion of an SCST.
ISSN:1341-8076
1447-0756
DOI:10.1111/jog.15107