Synthesis of 7-formyl methyl abietate via Vilsmeier-Haack reaction and cytotoxic activity of abietane diterpene derivatives

Synthesis of methyl 7-formylabieta-7,13-dien-18-oate was achieved by formylation of the abietic acid methyl ester under Vilsmeier-Haack conditions. The in vitro cytotoxicity of the abietic and dehydroabietic acid derivatives against the NCI-60 cancer cell line panel was also studied. The dehydroabie...

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Bibliographic Details
Main Authors: Tretyakova, E. V., Salimova, E. V., Parfenova, L. V.
Format: Conference Proceeding
Language:English
Subjects:
Anticancer properties
Cancer
Leukemia
Toxicity
Vilsmeier-Haack reaction
Online Access:Get full text
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Summary:Synthesis of methyl 7-formylabieta-7,13-dien-18-oate was achieved by formylation of the abietic acid methyl ester under Vilsmeier-Haack conditions. The in vitro cytotoxicity of the abietic and dehydroabietic acid derivatives against the NCI-60 cancer cell line panel was also studied. The dehydroabietic acid aminopropargyles showed promising antitumor activity against leukemia CCRF-CEM and RPMI-8226 cancer cell lines.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0069202