The impact of dietary saturated fat replacement with unsaturated fat on the plasma lipidome and cardiometabolic disease risk

Recent findings have suggested the utility of high-throughput lipidomics to identify potential CMD risk markers and provide novel aetiological insights into the relationship between dietary fat composition and CMD risk(2). [...]this study aimed to assess the lipidome-mediated impact of replacing die...

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Bibliographic Details
Published in:Proceedings of the Nutrition Society 2022, Vol.81 (OCE1), Article E51
Main Authors: Sellem, L., Eichelmann, F., Weech, M., Jackson, K.G., Schulze, M., Lovegrove, J.A.
Format: Article
Language:English
Subjects:
Algorithms
Fatty acids
Health risks
Lipids
Markers
Oils & fats
Plasma
Polyunsaturated fatty acids
Regression analysis
Regression models
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Summary:Recent findings have suggested the utility of high-throughput lipidomics to identify potential CMD risk markers and provide novel aetiological insights into the relationship between dietary fat composition and CMD risk(2). [...]this study aimed to assess the lipidome-mediated impact of replacing dietary SFAs with UFAs on CMD risk. Plasma fatty acid (FA) concentrations among 14 lipid classes were measured using high-throughput lipidomics analyses (Metabolon, USA) in samples from the DIVAS parallel RCT (n = 113), which investigated the effects of three 16-week diets enriched in SFAs (target SFA:monounsaturated fatty acids MUFA:n-6 polyunsaturated fatty acids PUFA ratio = 17:11:4% total energy TE), MUFAs (target SFA: [...]within- class FAs associated with changes in CMD risk markers assessed in the DIVAS study were identified using constraint-based feature selection algorithms and multiple linear regression models.
ISSN:0029-6651
1475-2719
DOI:10.1017/S0029665122000519