Multisystemic inflammatory syndrome related to COVID-19, with latent tuberculosis in bone marrow, and satisfactory response to tocilizumab, in a 7-year-old boy

Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) or multisystem inflammatory syndrome in children (MIS-C) is a new acute-onset systemic inflammatory disease, which mainly affects children. Latent tuberculosis infection (LTBI) is characterized by the presence...

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Published in:Reumatismo 2022-02, Vol.73 (4)
Main Authors: Morel, Z, Suarez, R, Avalos, E, Velázquez, S, Martínez, F, Lezcano, V, Astigarraga, N, Ghezzi, C, Brizuela, S, Samudio, G
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal, Humanized
Bone Marrow
Child
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - drug therapy
Humans
Latent Tuberculosis - complications
Latent Tuberculosis - diagnosis
Latent Tuberculosis - drug therapy
Male
Multisystem inflammatory syndrome in children
Multisystemic inflammatory syndrome in children
SARS-CoV-2
Systemic Inflammatory Response Syndrome
Tuberculosis
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container_issue 4
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container_title Reumatismo
container_volume 73
creator Morel, Z
Suarez, R
Avalos, E
Velázquez, S
Martínez, F
Lezcano, V
Astigarraga, N
Ghezzi, C
Brizuela, S
Samudio, G
description Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) or multisystem inflammatory syndrome in children (MIS-C) is a new acute-onset systemic inflammatory disease, which mainly affects children. Latent tuberculosis infection (LTBI) is characterized by the presence of immune sensitization to Mycobacterium tuberculosis (MTB) in the absence of any clinical or radiological evidence of active disease. We present a child with MIS-C related to COVID-19, with latent TB in the bone marrow, and satisfactory response to tocilizumab. It is important to pay attention in the investigation of TB cases in countries with a high prevalence of tuberculosis, especially when opting for immunusuppression.
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subjects Antibodies, Monoclonal, Humanized
Bone Marrow
Child
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - drug therapy
Humans
Latent Tuberculosis - complications
Latent Tuberculosis - diagnosis
Latent Tuberculosis - drug therapy
Male
Multisystem inflammatory syndrome in children
Multisystemic inflammatory syndrome in children
SARS-CoV-2
Systemic Inflammatory Response Syndrome
Tuberculosis
title Multisystemic inflammatory syndrome related to COVID-19, with latent tuberculosis in bone marrow, and satisfactory response to tocilizumab, in a 7-year-old boy
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