Synthesis of 3-substituted tetrahydroindol-4-one

A series of functionalized 4,5,6,7-tetrahydroindol-4-one derivatives containing a residue derived from β-dicarbonyl compound at position 3 were prepared by a reaction of cyclic enaminones, arylglyoxal hydrates, and β-dicarbonyl compounds. Modification of acetylacetone residue at position 3 of tetrah...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2021-12, Vol.57 (12), p.1181-1186
Main Authors: Kolos, Nadiia N., Marchenko, Kateryna I., Chechina, Nataliia V., Buravov, Alexander V., Omelchenko, Irina V.
Format: Article
Language:English
Subjects:
Acetylacetone
Carbonyl compounds
Chemistry
Chemistry and Materials Science
Hydrates
Organic Chemistry
Pharmacy
Residues
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Summary:A series of functionalized 4,5,6,7-tetrahydroindol-4-one derivatives containing a residue derived from β-dicarbonyl compound at position 3 were prepared by a reaction of cyclic enaminones, arylglyoxal hydrates, and β-dicarbonyl compounds. Modification of acetylacetone residue at position 3 of tetrahydroindoles was accomplished by condensation with 1,2- and 1,4-bisnucleophiles.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-021-03041-y