A Meta-Analysis of Cardiovascular Adaptive Responses to Temperature Variations in Normotensive Rats

• Published in: Biophysics (Oxford) 2021, Vol.66 (6), p.1016-1025
• Main Authors: Kuzmenko, N. V., Shcherbak, N. S., Pliss, M. G., Tsyrlin, V. A., Galagudza, M. M.
• Format: Article
• Language: English
• Subjects: Animal models; Biological and Medical Physics; Biophysics; Blood pressure; Cardiovascular system; Complex Systems Biophysics; Fever; Heart rate; Hyperthermia; Hypothermia; Meta-analysis; Physics; Physics and Astronomy; Rodents
• ISSN: 0006-3509; 1555-6654
• DOI: 10.1134/S0006350921060099

—In this paper we focus on a meta-analysis where the data from studies using rat models are combined to evaluate the effects of hypothermia and hyperthermia on the cardiovascular function. For this meta-analysis, 25 articles from the PubMed database were selected. The research aim of these reports was to investigate how whole-body hypothermia and hyperthermia in normotensive conscious adult rats affect hemodynamic parameters (systemic blood pressure and heart rate). The effects of short-term severe hyperthermia (40–43°C), prolonged moderate hyperthermia (32–34°C), and short-term and prolonged hypothermia (4–9°C, sudden and gradual, with and without any changes in photoperiod) were investigated. It has been shown that the blood pressure and heart rate patterns in normotensive conscious rats in response to a change in the ambient temperature are determined according not only to the vector field showing the direction of temperature change, but also to the amplitude, suddenness, duration of the change, and concomitant conditions (e.g., the duration of photoperiod).