Biosynthesized silver nanoparticles regulate the iron status in the spleen of Plasmodium chabaudi–infected mice

• Published in: Environmental science and pollution research international 2020-11, Vol.27 (32), p.40054-40060
• Main Authors: Murshed, Mutee, Dkhil, Mohamed A., Al-Shaebi, Esam M., Qasem, Mahmood A. A., Mares, Mohammed M., Aljawdah, Hossam M. A., Alojayri, Ghada, Abdel-Gaber, Rewaida, Al-Quraishy, Saleh
• Format: Article
• Language: English
• Subjects: Antiinfectives and antibacterials; Antimalarial activity; Antimalarial agents; Antimicrobial peptides; Aquatic Pollution; Atmospheric Protection/Air Quality Control/Air Pollution; Chloroquine; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; Environmental science; Gene expression; Genes; Health services; Hepcidin; Infrared spectroscopy; Iron; Lipocalin; Malaria; Nanoparticles; Parasitemia; Plant extracts; Plasmodium chabaudi; Research Article; Silver; Spleen; Transferrin; Transferrins; Vector-borne diseases; Waste Water Technology; Water Management; Water Pollution Control
• ISSN: 0944-1344; 1614-7499
• DOI: 10.1007/s11356-020-10027-4

Malaria is a dangerous disease affecting millions around the globe. Biosynthesized nanoparticles are used against a variety of diseases including malaria worldwide. Here, silver nanoparticles (AgNPs) synthesized from the leaf extracts of Indigofera oblongifolia have been used in the treatment of mice infected with Plasmodium chabaudi to evaluate the expression of iron regulatory genes in the spleen. Infrared spectroscopy was used to identify the expected classes of compounds in the extract. AgNPs were able to decrease the parasitemia nearly similar to the used reference drug, chloroquine. In addition, AgNPs significantly decreased the spleen index after infection. Moreover, the iron distribution was increased after the treatment. Finally, AgNPs could regulate the mice spleen iron regulatory genes, Lipocalin 2 ( Lcn2 ), transferrin receptor 1 ( TFR1 ) and hepcidin antimicrobial peptide ( Hamp ). Taken together, our findings indicate that AgNPs have antimalarial activity and can control the state of iron in spleen. We need further investigations to determine mechanisms of action of the AgNPs.