Synthesis and characterization of PEG coated hollow Fe3O4 magnetic nanoparticles as a drug carrier

•It is significant that the magnetic nanoparticles have excellent capacity for drug loading.•Fe3O4 nanorings and nanotubes had better magnetic properties than traditional Fe3O4 nanospheres.•The plyethylene glycol (PEG) was used as a surface modifier on magnetic nanoparticles for drug loading.•The do...

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Bibliographic Details
Published in:Materials letters 2022-02, Vol.309, p.131357, Article 131357
Main Authors: Da, Xianhong, Li, Ruonan, Li, Xiang, Lu, Yunshu, Gu, Fenfen, Liu, Yan
Format: Article
Language:English
Subjects:
Drug carriers
Drug loading
Fourier transforms
Hollow magnetic nanoparticles
Infrared analysis
Iron oxides
Magnetic nanorings
Magnetic nanotubes
Magnetic properties
Materials science
Nanoparticles
Nanospheres
Nanotubes
Structural analysis
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Summary:•It is significant that the magnetic nanoparticles have excellent capacity for drug loading.•Fe3O4 nanorings and nanotubes had better magnetic properties than traditional Fe3O4 nanospheres.•The plyethylene glycol (PEG) was used as a surface modifier on magnetic nanoparticles for drug loading.•The doxorubicin (DOX) was loaded on PEG-coated magnetic properties.•The MNPs with hollow structure have a better drug-carrying ability and are more suitable for the drug carrier system. As a drug carrier, the properties of magnetic nanoparticles for drug loading are significant. In this letter, three different shapes of magnetic nanoparticles for drug carrier systems were compared. We synthesized Fe3O4 magnetic nanospheres, nanorings and nanotubes, and plyethylene glycol was used as a surface modifier for drug loading. The structure characterization of three different shapes of Fe3O4 nanoparticles was elucidated by electron microscopy, and the composition was analyzed by Fourier transform infrared. The drug loading status and drug release of the three types of nanoparticles with different shapes were tested by Ultraviolet Spectrophometometer. The results show that the hollow Fe3O4 magnetic nanorings and nanotubes have better drug loading capacity and are more suitable for drug carriers, compared with nanospheres.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2021.131357