Recent advances in transition-metal-free trifluoromethylation with Togni's reagents

Transition-metal-free trifluoromethylations have attracted significant research interest driven by the increasing importance of CF3-containing compounds. Among the various trifluoromethylation reagents, Togni's reagents exhibit exceptional reactivities, and many important organic transformation...

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Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2022-02, Vol.9 (4), p.1152-1164
Main Authors: Jin-Yang, Chen, Huang, Jing, Sun, Kai, Wei-Min, He
Format: Article
Language:English
Subjects:
Chemical compounds
Metals
Organic chemistry
Reagents
Transition metals
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Summary:Transition-metal-free trifluoromethylations have attracted significant research interest driven by the increasing importance of CF3-containing compounds. Among the various trifluoromethylation reagents, Togni's reagents exhibit exceptional reactivities, and many important organic transformations have been realized employing such reagents. This review describes several key activation methods for Togni's reagents under transition-metal-free conditions by showcasing selected cornerstone research areas and related mechanisms to stimulate the interest of readers in participating in the development of novel efficient transition-metal-free trifluoromethylations with Togni's reagents.
ISSN:2052-4110
2052-4110
DOI:10.1039/d1qo01504d