Palladium‐Catalyzed Stereoselective Intramolecular Heck Dearomative Silylation of Indoles

A palladium‐catalyzed stereoselective intramolecular Heck dearomative of indoles with silyl termination has been developed. A type of tetracyclic indoline derivatives containing silicon were prepared, involving N‐(2‐bromobenzoyl)indoles and silylboronates. This protocol not only led to a broad subst...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2022-02, Vol.364 (4), p.909-913
Main Authors: Wang, Gang, Wei, Mingzhu, Liu, Tianxiang, Jin, Weiwei, Zhang, Yonghong, Wang, Bin, Xia, Yu, Liu, Chenjiang
Format: Article
Language:English
Subjects:
dearomatization
Heck reaction
indole
Indoles
Palladium
palladium-catalyzed
silylation
Stereoselectivity
Substrates
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Summary:A palladium‐catalyzed stereoselective intramolecular Heck dearomative of indoles with silyl termination has been developed. A type of tetracyclic indoline derivatives containing silicon were prepared, involving N‐(2‐bromobenzoyl)indoles and silylboronates. This protocol not only led to a broad substrate scope in acceptable yields but also could be scaled up to gram quantities as well as further synthetic transformation.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202101183