Loading…
Silica Nanoparticles Induce Hepatotoxicity by Triggering Oxidative Damage, Apoptosis, and Bax-Bcl2 Signaling Pathway
The increase in the usage of silica nanoparticles (SiNPs) in the industrial and medical fields has raised concerns about their possible adverse effects on human health. The present study aimed to investigate the potential adverse effects of SiNPs at daily doses of 25 and 100 mg/kg body weight intrap...
Saved in:
| Published in: | Biological trace element research 2022-04, Vol.200 (4), p.1688-1698 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c375t-128c774176620c0ded692c6215a2bab43fcffcbe40398fa18524aa46af7305473 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c375t-128c774176620c0ded692c6215a2bab43fcffcbe40398fa18524aa46af7305473 |
| container_end_page | 1698 |
| container_issue | 4 |
| container_start_page | 1688 |
| container_title | Biological trace element research |
| container_volume | 200 |
| creator | Aouey, Bakhta Boukholda, Khadija Gargouri, Brahim Bhatia, Harsharan S. Attaai, Abdelraheim Kebieche, Mohamed Bouchard, Michèle Fetoui, Hamadi |
| description | The increase in the usage of silica nanoparticles (SiNPs) in the industrial and medical fields has raised concerns about their possible adverse effects on human health. The present study aimed to investigate the potential adverse effects of SiNPs at daily doses of 25 and 100 mg/kg body weight intraperitoneally (i.p.) for 28 consecutive days on markers of liver damage in adult male rats. Results revealed that SiNPs induced a marked increase in serum markers of liver damage, including lactate dehydrogenase (LDH), alanine aminotransferase (ALAT), and aspartate aminotransferase (ASAT). SiNPs also induced an elevation of reactive oxygen species (ROS) production in liver, along with an increase in oxidative stress markers (NO, MDA, PCO, and H
2
O
2
), and a decrease in antioxidant enzyme activities (CAT, SOD, and GPx). Quantitative real-time PCR showed that SiNPs also induced upregulation of pro-apoptotic gene expression (including
Bax
,
p53
,
Caspase-9/3
) and downregulation of anti-apoptotic factors
Bcl-2
. Moreover, histopathological analysis revealed that SiNPs induced hepatocyte alterations, which was accompanied by sinusoidal dilatation, Kupffer cell hyperplasia, and the presence of inflammatory cells in the liver. Taken together, these data showed that SiNPs trigger hepatic damage through ROS-activated caspase signaling pathway, which plays a fundamental role in SiNP-induced apoptosis in the liver. |
| doi_str_mv | 10.1007/s12011-021-02774-3 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2629521885</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2629521885</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-128c774176620c0ded692c6215a2bab43fcffcbe40398fa18524aa46af7305473</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EgvL4ARbIElsCfsbJEspTQhQJWFsTxwlGaRJsF9q_J6UFdiys2Zx7x3MQOqTklBKizgJlhNKEsOVTSiR8A42olHlCFCObaERoyhORZ2IH7YbwRghVLOfbaIcLSolM5QjFJ9c4A_gB2q4HH51pbMB3bTkzFt_aHmIXu7kzLi5wscDP3tW19a6t8WTuSojuw-JLmEJtT_B53_WxCy6cYGhLfAHz5MI0DD-5uoVmmXmE-PoJi320VUET7MF67qGX66vn8W1yP7m5G5_fJ4YrGRPKMjOcRVWaMmJIacs0ZyZlVAIroBC8MlVlCisIz7MKaCaZABApVIoTKRTfQ8er3t537zMbon7rZn74S9AsZblkNMvkQLEVZXwXgreV7r2bgl9oSvRStF6J1oNo_S1a8yF0tK6eFVNb_kZ-zA4AXwGhX-qy_m_3P7Vf_-yIsg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2629521885</pqid></control><display><type>article</type><title>Silica Nanoparticles Induce Hepatotoxicity by Triggering Oxidative Damage, Apoptosis, and Bax-Bcl2 Signaling Pathway</title><source>Springer Link</source><creator>Aouey, Bakhta ; Boukholda, Khadija ; Gargouri, Brahim ; Bhatia, Harsharan S. ; Attaai, Abdelraheim ; Kebieche, Mohamed ; Bouchard, Michèle ; Fetoui, Hamadi</creator><creatorcontrib>Aouey, Bakhta ; Boukholda, Khadija ; Gargouri, Brahim ; Bhatia, Harsharan S. ; Attaai, Abdelraheim ; Kebieche, Mohamed ; Bouchard, Michèle ; Fetoui, Hamadi</creatorcontrib><description>The increase in the usage of silica nanoparticles (SiNPs) in the industrial and medical fields has raised concerns about their possible adverse effects on human health. The present study aimed to investigate the potential adverse effects of SiNPs at daily doses of 25 and 100 mg/kg body weight intraperitoneally (i.p.) for 28 consecutive days on markers of liver damage in adult male rats. Results revealed that SiNPs induced a marked increase in serum markers of liver damage, including lactate dehydrogenase (LDH), alanine aminotransferase (ALAT), and aspartate aminotransferase (ASAT). SiNPs also induced an elevation of reactive oxygen species (ROS) production in liver, along with an increase in oxidative stress markers (NO, MDA, PCO, and H
2
O
2
), and a decrease in antioxidant enzyme activities (CAT, SOD, and GPx). Quantitative real-time PCR showed that SiNPs also induced upregulation of pro-apoptotic gene expression (including
Bax
,
p53
,
Caspase-9/3
) and downregulation of anti-apoptotic factors
Bcl-2
. Moreover, histopathological analysis revealed that SiNPs induced hepatocyte alterations, which was accompanied by sinusoidal dilatation, Kupffer cell hyperplasia, and the presence of inflammatory cells in the liver. Taken together, these data showed that SiNPs trigger hepatic damage through ROS-activated caspase signaling pathway, which plays a fundamental role in SiNP-induced apoptosis in the liver.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-021-02774-3</identifier><identifier>PMID: 34110565</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alanine ; Alanine transaminase ; Animals ; Antioxidants ; Apoptosis ; Aspartate aminotransferase ; Bcl-2 protein ; bcl-2-Associated X Protein - genetics ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Body weight ; Caspase-9 ; Chemical and Drug Induced Liver Injury ; Damage ; Enzymatic activity ; Enzyme activity ; Gene expression ; Hepatocytes ; Hepatotoxicity ; Histopathology ; Hydrogen peroxide ; Hydrogen Peroxide - pharmacology ; Hyperplasia ; Inflammation ; L-Lactate dehydrogenase ; Lactate ; Lactate dehydrogenase ; Lactic acid ; Life Sciences ; Liver ; Male ; Markers ; Nanoparticles ; Nanoparticles - toxicity ; Nucleotide sequence ; Nutrition ; Oncology ; Oxidative Stress ; p53 Protein ; PCR ; Rats ; Reactive oxygen species ; Serum ; Side effects ; Signal Transduction ; Signaling ; Silica ; Silicon dioxide ; Silicon Dioxide - toxicity ; Transaminases</subject><ispartof>Biological trace element research, 2022-04, Vol.200 (4), p.1688-1698</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-128c774176620c0ded692c6215a2bab43fcffcbe40398fa18524aa46af7305473</citedby><cites>FETCH-LOGICAL-c375t-128c774176620c0ded692c6215a2bab43fcffcbe40398fa18524aa46af7305473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34110565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aouey, Bakhta</creatorcontrib><creatorcontrib>Boukholda, Khadija</creatorcontrib><creatorcontrib>Gargouri, Brahim</creatorcontrib><creatorcontrib>Bhatia, Harsharan S.</creatorcontrib><creatorcontrib>Attaai, Abdelraheim</creatorcontrib><creatorcontrib>Kebieche, Mohamed</creatorcontrib><creatorcontrib>Bouchard, Michèle</creatorcontrib><creatorcontrib>Fetoui, Hamadi</creatorcontrib><title>Silica Nanoparticles Induce Hepatotoxicity by Triggering Oxidative Damage, Apoptosis, and Bax-Bcl2 Signaling Pathway</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>The increase in the usage of silica nanoparticles (SiNPs) in the industrial and medical fields has raised concerns about their possible adverse effects on human health. The present study aimed to investigate the potential adverse effects of SiNPs at daily doses of 25 and 100 mg/kg body weight intraperitoneally (i.p.) for 28 consecutive days on markers of liver damage in adult male rats. Results revealed that SiNPs induced a marked increase in serum markers of liver damage, including lactate dehydrogenase (LDH), alanine aminotransferase (ALAT), and aspartate aminotransferase (ASAT). SiNPs also induced an elevation of reactive oxygen species (ROS) production in liver, along with an increase in oxidative stress markers (NO, MDA, PCO, and H
2
O
2
), and a decrease in antioxidant enzyme activities (CAT, SOD, and GPx). Quantitative real-time PCR showed that SiNPs also induced upregulation of pro-apoptotic gene expression (including
Bax
,
p53
,
Caspase-9/3
) and downregulation of anti-apoptotic factors
Bcl-2
. Moreover, histopathological analysis revealed that SiNPs induced hepatocyte alterations, which was accompanied by sinusoidal dilatation, Kupffer cell hyperplasia, and the presence of inflammatory cells in the liver. Taken together, these data showed that SiNPs trigger hepatic damage through ROS-activated caspase signaling pathway, which plays a fundamental role in SiNP-induced apoptosis in the liver.</description><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Aspartate aminotransferase</subject><subject>Bcl-2 protein</subject><subject>bcl-2-Associated X Protein - genetics</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Body weight</subject><subject>Caspase-9</subject><subject>Chemical and Drug Induced Liver Injury</subject><subject>Damage</subject><subject>Enzymatic activity</subject><subject>Enzyme activity</subject><subject>Gene expression</subject><subject>Hepatocytes</subject><subject>Hepatotoxicity</subject><subject>Histopathology</subject><subject>Hydrogen peroxide</subject><subject>Hydrogen Peroxide - pharmacology</subject><subject>Hyperplasia</subject><subject>Inflammation</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactate</subject><subject>Lactate dehydrogenase</subject><subject>Lactic acid</subject><subject>Life Sciences</subject><subject>Liver</subject><subject>Male</subject><subject>Markers</subject><subject>Nanoparticles</subject><subject>Nanoparticles - toxicity</subject><subject>Nucleotide sequence</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Oxidative Stress</subject><subject>p53 Protein</subject><subject>PCR</subject><subject>Rats</subject><subject>Reactive oxygen species</subject><subject>Serum</subject><subject>Side effects</subject><subject>Signal Transduction</subject><subject>Signaling</subject><subject>Silica</subject><subject>Silicon dioxide</subject><subject>Silicon Dioxide - toxicity</subject><subject>Transaminases</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EgvL4ARbIElsCfsbJEspTQhQJWFsTxwlGaRJsF9q_J6UFdiys2Zx7x3MQOqTklBKizgJlhNKEsOVTSiR8A42olHlCFCObaERoyhORZ2IH7YbwRghVLOfbaIcLSolM5QjFJ9c4A_gB2q4HH51pbMB3bTkzFt_aHmIXu7kzLi5wscDP3tW19a6t8WTuSojuw-JLmEJtT_B53_WxCy6cYGhLfAHz5MI0DD-5uoVmmXmE-PoJi320VUET7MF67qGX66vn8W1yP7m5G5_fJ4YrGRPKMjOcRVWaMmJIacs0ZyZlVAIroBC8MlVlCisIz7MKaCaZABApVIoTKRTfQ8er3t537zMbon7rZn74S9AsZblkNMvkQLEVZXwXgreV7r2bgl9oSvRStF6J1oNo_S1a8yF0tK6eFVNb_kZ-zA4AXwGhX-qy_m_3P7Vf_-yIsg</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Aouey, Bakhta</creator><creator>Boukholda, Khadija</creator><creator>Gargouri, Brahim</creator><creator>Bhatia, Harsharan S.</creator><creator>Attaai, Abdelraheim</creator><creator>Kebieche, Mohamed</creator><creator>Bouchard, Michèle</creator><creator>Fetoui, Hamadi</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20220401</creationdate><title>Silica Nanoparticles Induce Hepatotoxicity by Triggering Oxidative Damage, Apoptosis, and Bax-Bcl2 Signaling Pathway</title><author>Aouey, Bakhta ; Boukholda, Khadija ; Gargouri, Brahim ; Bhatia, Harsharan S. ; Attaai, Abdelraheim ; Kebieche, Mohamed ; Bouchard, Michèle ; Fetoui, Hamadi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-128c774176620c0ded692c6215a2bab43fcffcbe40398fa18524aa46af7305473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Apoptosis</topic><topic>Aspartate aminotransferase</topic><topic>Bcl-2 protein</topic><topic>bcl-2-Associated X Protein - genetics</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Body weight</topic><topic>Caspase-9</topic><topic>Chemical and Drug Induced Liver Injury</topic><topic>Damage</topic><topic>Enzymatic activity</topic><topic>Enzyme activity</topic><topic>Gene expression</topic><topic>Hepatocytes</topic><topic>Hepatotoxicity</topic><topic>Histopathology</topic><topic>Hydrogen peroxide</topic><topic>Hydrogen Peroxide - pharmacology</topic><topic>Hyperplasia</topic><topic>Inflammation</topic><topic>L-Lactate dehydrogenase</topic><topic>Lactate</topic><topic>Lactate dehydrogenase</topic><topic>Lactic acid</topic><topic>Life Sciences</topic><topic>Liver</topic><topic>Male</topic><topic>Markers</topic><topic>Nanoparticles</topic><topic>Nanoparticles - toxicity</topic><topic>Nucleotide sequence</topic><topic>Nutrition</topic><topic>Oncology</topic><topic>Oxidative Stress</topic><topic>p53 Protein</topic><topic>PCR</topic><topic>Rats</topic><topic>Reactive oxygen species</topic><topic>Serum</topic><topic>Side effects</topic><topic>Signal Transduction</topic><topic>Signaling</topic><topic>Silica</topic><topic>Silicon dioxide</topic><topic>Silicon Dioxide - toxicity</topic><topic>Transaminases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aouey, Bakhta</creatorcontrib><creatorcontrib>Boukholda, Khadija</creatorcontrib><creatorcontrib>Gargouri, Brahim</creatorcontrib><creatorcontrib>Bhatia, Harsharan S.</creatorcontrib><creatorcontrib>Attaai, Abdelraheim</creatorcontrib><creatorcontrib>Kebieche, Mohamed</creatorcontrib><creatorcontrib>Bouchard, Michèle</creatorcontrib><creatorcontrib>Fetoui, Hamadi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aouey, Bakhta</au><au>Boukholda, Khadija</au><au>Gargouri, Brahim</au><au>Bhatia, Harsharan S.</au><au>Attaai, Abdelraheim</au><au>Kebieche, Mohamed</au><au>Bouchard, Michèle</au><au>Fetoui, Hamadi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Silica Nanoparticles Induce Hepatotoxicity by Triggering Oxidative Damage, Apoptosis, and Bax-Bcl2 Signaling Pathway</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>200</volume><issue>4</issue><spage>1688</spage><epage>1698</epage><pages>1688-1698</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>The increase in the usage of silica nanoparticles (SiNPs) in the industrial and medical fields has raised concerns about their possible adverse effects on human health. The present study aimed to investigate the potential adverse effects of SiNPs at daily doses of 25 and 100 mg/kg body weight intraperitoneally (i.p.) for 28 consecutive days on markers of liver damage in adult male rats. Results revealed that SiNPs induced a marked increase in serum markers of liver damage, including lactate dehydrogenase (LDH), alanine aminotransferase (ALAT), and aspartate aminotransferase (ASAT). SiNPs also induced an elevation of reactive oxygen species (ROS) production in liver, along with an increase in oxidative stress markers (NO, MDA, PCO, and H
2
O
2
), and a decrease in antioxidant enzyme activities (CAT, SOD, and GPx). Quantitative real-time PCR showed that SiNPs also induced upregulation of pro-apoptotic gene expression (including
Bax
,
p53
,
Caspase-9/3
) and downregulation of anti-apoptotic factors
Bcl-2
. Moreover, histopathological analysis revealed that SiNPs induced hepatocyte alterations, which was accompanied by sinusoidal dilatation, Kupffer cell hyperplasia, and the presence of inflammatory cells in the liver. Taken together, these data showed that SiNPs trigger hepatic damage through ROS-activated caspase signaling pathway, which plays a fundamental role in SiNP-induced apoptosis in the liver.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34110565</pmid><doi>10.1007/s12011-021-02774-3</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-4984 |
| ispartof | Biological trace element research, 2022-04, Vol.200 (4), p.1688-1698 |
| issn | 0163-4984 1559-0720 |
| language | eng |
| recordid | cdi_proquest_journals_2629521885 |
| source | Springer Link |
| subjects | Alanine Alanine transaminase Animals Antioxidants Apoptosis Aspartate aminotransferase Bcl-2 protein bcl-2-Associated X Protein - genetics Biochemistry Biomedical and Life Sciences Biotechnology Body weight Caspase-9 Chemical and Drug Induced Liver Injury Damage Enzymatic activity Enzyme activity Gene expression Hepatocytes Hepatotoxicity Histopathology Hydrogen peroxide Hydrogen Peroxide - pharmacology Hyperplasia Inflammation L-Lactate dehydrogenase Lactate Lactate dehydrogenase Lactic acid Life Sciences Liver Male Markers Nanoparticles Nanoparticles - toxicity Nucleotide sequence Nutrition Oncology Oxidative Stress p53 Protein PCR Rats Reactive oxygen species Serum Side effects Signal Transduction Signaling Silica Silicon dioxide Silicon Dioxide - toxicity Transaminases |
| title | Silica Nanoparticles Induce Hepatotoxicity by Triggering Oxidative Damage, Apoptosis, and Bax-Bcl2 Signaling Pathway |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T08%3A05%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Silica%20Nanoparticles%20Induce%20Hepatotoxicity%20by%20Triggering%20Oxidative%20Damage,%20Apoptosis,%20and%20Bax-Bcl2%20Signaling%20Pathway&rft.jtitle=Biological%20trace%20element%20research&rft.au=Aouey,%20Bakhta&rft.date=2022-04-01&rft.volume=200&rft.issue=4&rft.spage=1688&rft.epage=1698&rft.pages=1688-1698&rft.issn=0163-4984&rft.eissn=1559-0720&rft_id=info:doi/10.1007/s12011-021-02774-3&rft_dat=%3Cproquest_cross%3E2629521885%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c375t-128c774176620c0ded692c6215a2bab43fcffcbe40398fa18524aa46af7305473%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2629521885&rft_id=info:pmid/34110565&rfr_iscdi=true |