Chitosan hydrogel, as a biological macromolecule-based drug delivery system for exosomes and microvesicles in regenerative medicine: a mini review

Extracellular vesicles are membrane-packed entities that are involved in various physiological and pathological processes. Recently, the role of exosomes and microvesicles in regenerative medicine has been elucidated. Indeed, therapeutic potential of stem cells may be partly due to exosomes or micro...

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Bibliographic Details
Published in:Cellulose (London) 2022-02, Vol.29 (3), p.1315-1330
Main Authors: Guo, Lan, Guan, Yali, Liu, Peng, Gao, Linghuan, Wang, Zhifu, Huang, Shengli, Peng, Liang, Zhao, Zhiyu
Format: Article
Language:English
Subjects:
Bioorganic Chemistry
Ceramics
Chemistry
Chemistry and Materials Science
Chitosan
Composites
Drug delivery systems
Glass
Hydrogels
Natural Materials
Organic Chemistry
Physical Chemistry
Polymer Sciences
Review Paper
Stem cells
Sustainable Development
Vesicles
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Summary:Extracellular vesicles are membrane-packed entities that are involved in various physiological and pathological processes. Recently, the role of exosomes and microvesicles in regenerative medicine has been elucidated. Indeed, therapeutic potential of stem cells may be partly due to exosomes or microvesicles. However, injection of these vesicles may lead to their rapid clearance from the injection site. To address this challenge, different delivery systems for these vesicles’ sustained delivery have been developed. In this regard, chitosan based hydrogels have been successfully utilized as delivery platforms for exosomes and microvesicles. In the current review, the prospects, challenges, and applications of chitosan-based hydrogels as a delivery vehicle for exosomes and microvesicles will be discussed.
ISSN:0969-0239
1572-882X
DOI:10.1007/s10570-021-04330-7