Long Non-coding RNAs: Potential Players in Cardiotoxicity Induced by Chemotherapy Drugs

One of the most important side effects of chemotherapy is cardiovascular complications, such as cardiotoxicity. Many factors are involved in the pathogenesis of cardiotoxicity; one of the most important of which is long non-coding RNAs (lncRNAs). lncRNA has 200–1000 nucleotides. It is involved in im...

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Bibliographic Details
Published in:Cardiovascular toxicology 2022-03, Vol.22 (3), p.191-206
Main Authors: Amrovani, Mehran, Mohammadtaghizadeh, Mohammadjavad, Aghaali, Mahsa Karimzadeh, Zamanifard, Somayeh, Alqasi, Arash, Sanei, Mozhdeh
Format: Article
Language:English
Subjects:
Apoptosis
Biomedical and Life Sciences
Biomedicine
Cancer
Cardiology
Cardiotoxicity
Cell Proliferation
Chemotherapy
Coding
Complications
Complications and side effects
Drug development
Drugs
Drugs and athletes
Humans
Non-coding RNA
Nucleotides
Pharmacology/Toxicology
Prognosis
Regeneration
RNA, Long Noncoding - genetics
RNA, Long Noncoding - pharmacology
Side effects
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Summary:One of the most important side effects of chemotherapy is cardiovascular complications, such as cardiotoxicity. Many factors are involved in the pathogenesis of cardiotoxicity; one of the most important of which is long non-coding RNAs (lncRNAs). lncRNA has 200–1000 nucleotides. It is involved in important processes such as cell proliferation, regeneration and apoptosis; today it is used as a prognostic and diagnostic factor. A, various drugs by acting on lncRNAs can affect cells. Therefore, by accurately identifying IncRNAs function, we can play an effective role in preventing the development of cardiotoxicity-induced chemotherapy drugs, and use them as a therapeutic strategy to improve clinical symptoms and increase patient survival.
ISSN:1530-7905
1559-0259
DOI:10.1007/s12012-021-09681-y