An expedient, efficient and solvent-free synthesis of T3P®-mediated amidation of benzhydrols with poorly reactive N-nucleophiles under MW irradiation

An expedient, efficient, economical, environmentally benign, and solvent free amidation protocol of benzhydrols with less reactive nitrogen nucleophiles assisted by propylphosphonic anhydride (T3P®) under microwave irradiation has been developed. The methodology has been deployed for a wide range of...

Full description

Saved in:
Bibliographic Details
Published in:New journal of chemistry 2022-02, Vol.46 (9), p.4421-4426
Main Authors: Cheruku, Srinivas, Nagarakere, Sandhya C., Sunilkumar, Makanahalli P., Narayana, Yatheesh, Manikyanally, Kumara N., Rangappa, Kanchugarakoppal S., Mantelingu, Kempegowda
Format: Article
Language:English
Subjects:
Irradiation
Nitrogen
Nucleophiles
Solvents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An expedient, efficient, economical, environmentally benign, and solvent free amidation protocol of benzhydrols with less reactive nitrogen nucleophiles assisted by propylphosphonic anhydride (T3P®) under microwave irradiation has been developed. The methodology has been deployed for a wide range of heterocycles and electron-withdrawing & electron-donating groups. The protocol resulted in good to excellent yields under the given conditions (26 examples, 68–93% yield).
ISSN:1144-0546
1369-9261
DOI:10.1039/D1NJ04502D