[TBP]2SO4 ionic liquid catalyst for 4MCR of pyridazinoindazole, indazolophthalazine and pyrazolophthalazine derivatives

Tetrabutyl phosphonium sulfate ([TBP] 2 SO 4 ), as novel room-temperature ionic liquid (RTIL), was synthesized by a simple cost-effective method, characterized by 1 H, 13 C, 31 P NMR and FT-IR spectrophotometry. The newly prepared catalyst was used as an efficient catalyst in some four multicomponen...

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Bibliographic Details
Published in:Molecular diversity 2022-02, Vol.26 (1), p.15-25
Main Authors: Amirmahani, Najmeh, Mahmoodi, Nosrat O., Malakootian, Mohammad, Pardakhty, Abbas
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Ions
Life Sciences
Organic Chemistry
Original Article
Pharmacy
Polymer Sciences
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Summary:Tetrabutyl phosphonium sulfate ([TBP] 2 SO 4 ), as novel room-temperature ionic liquid (RTIL), was synthesized by a simple cost-effective method, characterized by 1 H, 13 C, 31 P NMR and FT-IR spectrophotometry. The newly prepared catalyst was used as an efficient catalyst in some four multicomponent reactions (4MCRs) e. g., to synthesis pyridazino[1,2- a ]indazole, indazolo[2,1- b ]phthalazine and pyrazolo[1,2- b ]phthalazine. This green method has several advantages such as short reaction time, using simple methods to prepare catalysts and products, easy operation and high efficiency of products. In addition, the catalyst can be easily recovered and reused several times with reduced average activity. Graphic abstract
ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-020-10153-8