A comparison of chiral separations by supercritical fluid chromatography and high-performance liquid chromatography

The supercritical fluid chromatography technique is one of the most promising and innovative technologies used in the analysis as well as the separation of various racemates. The various enantiomers have been separated using SFC due to its several merits over conventional HPLC methods such as low co...

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Bibliographic Details
Published in:Journal of liquid chromatography & related technologies 2021-07, Vol.44 (11-12), p.550-563
Main Authors: Ali, Imran, Raja, Rupak, Alam, Syed Dilshad, Shirsath, Vikas, K. Jain, Arvind, Locatelli, Marcello, David, Victor
Format: Article
Language:English
Subjects:
Chiral separation
Chromatography
comparison
Cost analysis
Enantiomers
future perspectives
High performance liquid chromatography
Laboratories
Liquid chromatography
Literature reviews
Pharmaceutical industry
Pharmaceuticals
Polarity
Separation
Solvents
supercritical fluid chromatography
Supercritical fluids
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Summary:The supercritical fluid chromatography technique is one of the most promising and innovative technologies used in the analysis as well as the separation of various racemates. The various enantiomers have been separated using SFC due to its several merits over conventional HPLC methods such as low cost, wide polarity compatibility, higher column efficiency, and fast analyzing capability, which are desirable features for the pharmaceutical industry. Therefore, it was considered worthwhile to review the applications of SFC in achiral and chiral separations. This review encompasses the latest literature exploration of various practical aspects of SFC for enantiomeric separation, purification, and applications to the pharmaceutical industry. A detailed discussion of SFC was made in terms of productivity, stacked injections, sample solubility, particle size, green incentive, organic solvent, recycle solvents, and economical aspects. Besides, future perspectives of SFC have also been highlighted. A comparison was also made between SFC and HPLC. SFC has been found better technique than HPLC for the chiral separations on a preparative scale. This article will be highly useful for chiral chromatography in pharmaceutical industries and research laboratories.
ISSN:1082-6076
1520-572X
DOI:10.1080/10826076.2021.1979037