Two New Anti-Tobacco Mosaic Virus Quinoline Alkaloids from the Stems of Nicotiana tabacum

Two new quinoline alkaloids, 4-acetyl-7-isopropyl-6-methylquinolin-2(1H)-one ( 1 ) and 4-acetyl-7-isopropyl-5-methylquinolin-2(1H)-one ( 2 ), were isolated from the stems of Nicotiana tabacum . Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies....

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Bibliographic Details
Published in:Chemistry of natural compounds 2022, Vol.58 (1), p.78-81
Main Authors: Deng, Le-Le, Yang, Wen-Wu, Jiang, Jia-Rui, Xu, Li, Zhang, Jian-Duo, Liu, Chun-Bo, Ling, Jun, Kong, Wei-Song, Li, Xue-Mei, Li, Yin-Ke, Liu, Xin, Zhou, Tao
Format: Article
Language:English
Subjects:
Alkaloids
Antismoking movement
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
NMR
Nuclear magnetic resonance
Organic Chemistry
Plant Sciences
Quinoline
Tobacco
Viruses
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Summary:Two new quinoline alkaloids, 4-acetyl-7-isopropyl-6-methylquinolin-2(1H)-one ( 1 ) and 4-acetyl-7-isopropyl-5-methylquinolin-2(1H)-one ( 2 ), were isolated from the stems of Nicotiana tabacum . Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 38.5 and 42.2% at the concentration of 20 μM, respectively. These rates are higher than that of positive control.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-022-03600-5