A carboxylatopillar[5]arene-based pH-triggering supramolecular photosensitizer for enhanced photodynamic antibacterial efficacy

A pH-triggering supramolecular antibacterial photosensitizer was constructed by host-guest interaction between a water-soluble porphyrin photosensitizer and carboxylatopillar[5]arene (P[5]). The formation of the supramolecular complex not only improves the biocompatibility of the photosensitizer, bu...

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Published in:Chemical communications (Cambridge, England) England), 2022-03, Vol.58 (18), p.2991-2994
Main Authors: Yue, Tao, Xia, Lei, Tian, Jia, Huang, Baoxuan, Chen, Chao, Cao, Hongliang, Zhang, Weian
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antiinfectives and antibacterials
Biocompatibility
Escherichia coli - drug effects
Hydrocarbons, Aromatic - chemistry
Hydrocarbons, Aromatic - pharmacology
Microbial Sensitivity Tests
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Porphyrins
Spectrometry, Fluorescence
Spectrophotometry, Ultraviolet
Staphylococcus aureus - drug effects
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Summary:A pH-triggering supramolecular antibacterial photosensitizer was constructed by host-guest interaction between a water-soluble porphyrin photosensitizer and carboxylatopillar[5]arene (P[5]). The formation of the supramolecular complex not only improves the biocompatibility of the photosensitizer, but also enhances antibacterial efficacy by pH-triggering dissociation under the low pH bacterial microenvironment. A pH-triggering supramolecular antibacterial photosensitizer, constructed by host-guest interaction between porphyrin photosensitizer and carboxylatopillar[5]arene, not only improves the biocompatibility of the photosensitizer, but also enhances antibacterial efficacy under the low pH bacterial microenvironment.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc06116j