Extraskeletal Mesenchymal Chondrosarcoma of Central Nervous System - A Rare but Aggressive Tumor: Analysis of Five Cases

Background: Extraskeletal mesenchymal chondrosarcoma (MCS) of the central nervous system (CNS) is extremely rare. Herein, we present the clinicopathological features of five CNS extraskeletal MCS. Material and Methods: Over the past 10 years, five cases of CNS MCS have been retrieved from in the arc...

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Published in:Neurology India 2022-01, Vol.70 (1), p.285-288
Main Authors: Chatterjee, Debajyoti, Radotra, Bishan, Madan, Renu, Gupta, Sunil
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Language:English
Subjects:
Bone cancer
Brain cancer
Case studies
Central nervous system diseases
Chondrosarcoma
Nervous system
Rare diseases
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description Background: Extraskeletal mesenchymal chondrosarcoma (MCS) of the central nervous system (CNS) is extremely rare. Herein, we present the clinicopathological features of five CNS extraskeletal MCS. Material and Methods: Over the past 10 years, five cases of CNS MCS have been retrieved from in the archives of histopathology department. All biopsies were stained with vimentin, S-100, CD99, desmin, GFAP, INI1, WT1, STAT6, and EMA. Results: There were four males and one female patient in the age group of 1.5-35 years. The clinical and radiological impression was meningioma in three cases, glomus jugulare and primitive neuroectodermal tumor in one case each. All showed classic biphasic morphology, areas of undifferentiated small blue round cells sharply demarcated from the island of cartilage. Three patients experienced multiple recurrences and died subsequently. Conclusion: Extraskeletal MCS of CNS is rare and favors children and young adults. They show aggressive behavior and tend to recur despite surgery and radiotherapy.
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subjects Bone cancer
Brain cancer
Case studies
Central nervous system diseases
Chondrosarcoma
Nervous system
Rare diseases
title Extraskeletal Mesenchymal Chondrosarcoma of Central Nervous System - A Rare but Aggressive Tumor: Analysis of Five Cases
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