Emerging SARS-CoV-2 B.1.621/Mu variant is prominently resistant to inactivated vaccine-elicited antibodies

Based on spike mutations, the Mu variant is distinguishable from the Delta variant (Figure 1B), with the latter possessing strong transmission capacity and currently accounting for most COVID-19 cases worldwide. [...]we examined the effect of the spike mutations on infectivity of the Mu variant usin...

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Published in:Dōngwùxué yánjiū 2021-11, Vol.42 (6), p.789-791
Main Authors: Xie, Xiaochun, Han, Jian-Bao, Ma, Guanqin, Feng, Xiao-Li, Li, Xiaohong, Zou, Qing-Cui, Deng, Zhong-Hua, Zeng, Jianxiong
Format: Article
Language:English
Subjects:
Animal diseases
Animal models
Antibodies
Biosafety
Coronaviruses
COVID-19
COVID-19 vaccines
Deactivation
Disease control
Disease transmission
Epidemiology
Genetic analysis
Human diseases
Infections
Infectivity
Laboratories
mRNA
mRNA vaccines
Mutation
Pandemics
Primates
Proteins
Research facilities
Severe acute respiratory syndrome coronavirus 2
Signal transduction
Vaccines
Zoology
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Summary:Based on spike mutations, the Mu variant is distinguishable from the Delta variant (Figure 1B), with the latter possessing strong transmission capacity and currently accounting for most COVID-19 cases worldwide. [...]we examined the effect of the spike mutations on infectivity of the Mu variant using lentiviral pseudotyped SARS-CoV-2 with luciferase reporter. Considering the high immune resistance of Mu to inactivated and mRNA vaccines, which are commonly used worldwide, further global epidemiological monitoring of this variant is required. [...]the above findings strongly call for emergent evaluation of the protective efficacy of current COVID-19 vaccines against the Mu variant. Xiaochun Xie1, Jian-Bao Han2, Guanqin Ma1, Xiao-Li Feng2, Xiaohong Li1, Qing-Cui Zou2, Zhong-Hua Deng2, Jianxiong Zeng1,2,3 1 Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China 2 Kunming National High-level Biosafety Research Center for Non-Human Primates, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650107, China 3 National Resource Center for Non-Human Primates, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650107, China This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ISSN:0254-5853
DOI:10.24272/j.issn.2095-8137.2021.343